ArticleHypertension research : official journal of the Japanese Society of Hypertension2024
Remnant cholesterol and risk of incident hypertension: a population-based prospective cohort study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Remnant cholesterol and two decades risk of incident hypertension: a prospective cohort study and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- Association of non-conventional lipid-inflammatory parameters with incident hypertension risk: a prospective cohort study.Journal of global health · 2026Article
- Discordance between remnant cholesterol and low-density lipoprotein cholesterol predicts incident hypertension: a 9-year prospective cohort study in Chinese adults.BMC cardiovascular disorders · 2026Article
- Article
- Cumulative exposure to remnant cholesterol and new-onset hypertension in middle-aged and older adults: a nationwide prospective cohort study with mediation analysis.Journal of human hypertension · 2026Article
- Association between remnant cholesterol and isolated diastolic hypertension in young adults: a cross-sectional study in China.BMC cardiovascular disorders · 2026Article
- Exploring the relationship between remnant cholesterol and diabetic kidney disease in Chinese type 2 diabetes patients.Frontiers in nutrition · 2026Article
- Predictive Value of Residual Cholesterol Inflammatory Index for Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Nonvalvular Atrial Fibrillation with Low CHAInternational journal of general medicine · 2026Article
- Combined effects of insulin resistance and dyslipidaemia on cardiometabolic multimorbidity in Chinese middle-age and older adults: a longitudinal cohort study.Scientific reports · 2025Observational
- Exploring the relationship between residual cholesterol, body mass index, and hypertension risk: a national cohort study.Lipids in health and disease · 2025Observational
- Association of remnant cholesterol with new-onset hypertension among middle-aged and older adults in China.Scientific reports · 2025Article
- Cholesterol's hidden impact: the nonlinear link between remnant cholesterol (RC) and phenotypic age acceleration (PhenoAgeAccel).Biogerontology · 2025Article
- Observational
- Association between remnant cholesterol (RC) and endometriosis: a cross-sectional study based on NHANES data.Lipids in health and disease · 2025Article
- Remnant cholesterol: an independent, dose-dependent risk factor for hyperuricemia in a normolipidemic chinese population.Frontiers in endocrinology · 2025Article
- Association between remnant cholesterol and depression in middle-aged and older Chinese adults: a population-based cohort study.Frontiers in endocrinology · 2025Article
- Joint Association of Remnant Cholesterol and Body Mass Index with Hypertension: A National Cohort Study in Chinese Adults.Journal of multidisciplinary healthcare · 2025Article
- Remnant cholesterol, not LDL cholesterol, is associated with the risk of hypertension in the middle-aged and elderly population: Bushehr Elderly Health cohort.Frontiers in cardiovascular medicine · 2025Article
- Nonlinear association of a composite metabolic index (ZJU index) with hypertension: a cross-sectional study of NHANES 2003-2018.Frontiers in cardiovascular medicine · 2025Article
- Association between Remnant Cholesterol and Metabolic Syndrome among Chinese Adults: Chinese Nutrition and Health Surveillance (2015-2017).Nutrients · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Remnant cholesterol (RC) has been associated with atherosclerotic cardiovascular disease, but its relationship with hypertension remains unclear. This prospective cohort study aimed to investigate the association between RC and subsequent hypertension risk. Data from the UK Biobank, comprising 295,062 participants initially free of hypertension, were analyzed. Cox proportional hazards regression assessed the association between RC quartiles and hypertension risk. Discordance analysis evaluated the risk of hypertension in discordant/concordant groups of RC and low-density lipoprotein cholesterol (LDL-C) using the difference in percentile units (>10 units). Restricted cubic spline curves were used to model the relationship between RC and hypertension risk. The mean ± SD age of participants was 55.1 ± 8.1 years, with 40.6% being men and 94.7% White. During a median follow-up of 12.8 years, 39,038 participants developed hypertension. Comparing extreme quartiles of RC, the hazard ratio (HR) for incident hypertension was 1.20 (95% CI: 1.17-1.24). After adjusting for traditional risk factors, each 1 mmol/L increase in RC levels was associated with a 27% higher risk of incident hypertension (HR: 1.27; 95% CI: 1.23-1.31). The discordant group with high RC/low LDL-C exhibited a higher risk of incident hypertension compared to the concordant group (HR: 1.06; 95% CI: 1.03-1.09). Spline curves further demonstrated a positive association between RC and the risk of incident hypertension. We concluded that elevated RC emerged as an independent risk factor of incident hypertension, extending beyond traditional risk factors. Monitoring RC levels and implementing interventions to lower RC may have potential benefits in preventing hypertension.
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