ArticleCerebral cortex (New York, N.Y. : 1991)2024
The significance and limited influence of cerebrovascular reactivity on age and sex effects in task- and resting-state brain activity.
Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 citing papers in PubMed, 7 citations in OpenAlex.
- Sexual Dimorphisms in Neurodevelopment May Affect TBI Recovery in Pediatric Patients.Biomedicines · 2025Review
- Timing Is Everything: Temporal Dynamics of BOLD Responses to Naturalistic Features in Movie Watching.bioRxiv : the preprint server for biology · 2025Article
- Effects of resistance exercise intensity on cerebral blood flow and cerebrovascular reactivity in healthy young males: A pilot study.Physiological reports · 2025Article
- Intermittent theta burst stimulation enhances prefrontal activation and connectivity: evidence from fNIRS.Frontiers in human neuroscience · 2025Article
- Cerebrovascular reactivity mapping using breath-hold BOLD-fMRI: Comparison of signal models combined with voxelwise lag optimization.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex-specific cerebrovascular reactivity differences in autistic children related to functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Delayed cerebrovascular reactivity in individuals with spinal cord injury in the right inferior parietal lobe: a breath-hold functional near-infrared spectroscopy study.medRxiv : the preprint server for health sciences · 2024Article
- Beyond the canonical HRF: Flexible temporal modeling reveals unconstrained BOLD profiles during naturalistic viewing.Imaging neuroscience (Cambridge, Mass.)Article
- The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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4 authors at 3 institutions in 1 country.
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Abstract
Functional MRI measures the blood-oxygen-level dependent signals, which provide an indirect measure of neural activity mediated by neurovascular responses. Cerebrovascular reactivity affects both task-induced and resting-state blood-oxygen-level dependent activity and may confound inter-individual effects, such as those related to aging and biological sex. We examined a large dataset containing breath-holding, checkerboard, and resting-state tasks. We used the breath-holding task to measure cerebrovascular reactivity, used the checkerboard task to obtain task-based activations, and quantified resting-state activity with amplitude of low-frequency fluctuations and regional homogeneity. We hypothesized that cerebrovascular reactivity would be correlated with blood-oxygen-level dependent measures and that accounting for these correlations would result in better estimates of age and sex effects. We found that cerebrovascular reactivity was correlated with checkerboard task activations in the visual cortex and with amplitude of low-frequency fluctuations and regional homogeneity in widespread fronto-parietal regions, as well as regions with large vessels. We also found significant age and sex effects in cerebrovascular reactivity, some of which overlapped with those observed in amplitude of low-frequency fluctuations and regional homogeneity. However, correcting for the effects of cerebrovascular reactivity had very limited influence on the estimates of age and sex. Our results highlight the limitations of accounting for cerebrovascular reactivity with the current breath-holding task.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.