ArticleJournal for immunotherapy of cancer2024
Open access · goldAbstract read
In one paragraph
Article in Journal for immunotherapy of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 13 citations in OpenAlex.
- The Role of Monoclonal Antibody Targeted Therapy (Panitumumab) in the Treatment of Metastatic Colorectal Cancer-A Narrative Review of Current Evidence and Emerging Therapeutic Strategies.International journal of molecular sciences · 2026Review
- Targeting cytokine/chemokine signaling to convert immunologically cold tumors into hot: Emerging strategies in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2026Review
- CCR5+ CD8+ T Cells Are Associated with Poor Response to PD-1 Blockade Therapy.International journal of molecular sciences · 2026Article
- Glycolysis-driven cancer-associated fibroblasts shape T-Cell exclusion via the CXCL16-CXCR6 Axis: a metabolic-chemokine mechanism in tumor immunity.Journal of translational medicine · 2026Review
- CCL5 promotes colon cancer progression via PI3K/AKT signaling and is negatively regulated by STAT1.Journal of gastrointestinal oncology · 2026Article
- Mechanisms of transcriptional regulation of CCR5, which is the co-receptor for R5-tropic HIV and is also involved in other disease processes.Biochemical Society transactions · 2026Review
- CEA-targeted CAR-NK cells derived from embryonic stem cells exhibit potent anti-tumor activity against colorectal cancer.Frontiers in immunology · 2026Article
- The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications.Biomedicines · 2025Review
- The mechanisms and clinical significance of CD8Cancer biology & medicine · 2025Review
- Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects against tumor rechallenge in mice.Journal for immunotherapy of cancer · 2025Article
- Could Silent Inflammation Originating in Jawbone Cavitations Play a Role in Activating the CCL5/CCR5 Axis in Female Breast Cancer? A Diagnostic and Therapeutic Gap in Osteoimmunological Interactions.OncoTargets and therapy · 2025Article
- Exploring Predictive and Prognostic Biomarkers in Colorectal Cancer: A Comprehensive Review.Cancers · 2024Review
- CCR5 and CCL5 in metastatic colorectal cancer.Journal for immunotherapy of cancer · 2024Article
- Mismatch repair-proficient tumor footprints in the sands of immune desert: mechanistic constraints and precision platforms.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 10 institutions in 2 countries.
Francesca BattaglinUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA fbattagl@usc.edu.ORCID 0000-0002-9869-0163
Yasmine BacaCaris Life Sciences, Phoenix, Arizona, USA.
Joshua MillsteinDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Yan YangDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Joanne XiuCaris Life Sciences, Phoenix, Arizona, USA.
Hiroyuki AraiUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.ORCID 0000-0002-1886-7070
Jingyuan WangUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Fang-Shu OuAlliance Statistics and Data Management Center, Mayo Clinic, Rochester, Minnesota, USA.
Federico InnocentiUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Shannon M MumenthalerUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Priya JayachandranUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Natsuko KawanishiUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Annika LenzUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Shivani SoniUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Sandra AlgazeUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Wu ZhangUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Taline KhoukazUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Evanthia Roussos TorresUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
Andreas SeeberDepartment of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Innsbruck Medical University, Innsbruck, Tirol, Austria.
Jim P AbrahamCaris Life Sciences, Phoenix, Arizona, USA.
Emil LouDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-1607-1386
Philip A PhilipDepartment of Oncology and Pharmacology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Benjamin A WeinbergRuesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
Anthony F ShieldsDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Richard M GoldbergWest Virginia University Cancer Institute, Morgantown, West Virginia, USA.
John L MarshallRuesch Center for the Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
Alan P VenookUniversity of California San Francisco, San Francisco, California, USA.
W Michael KornCaris Life Sciences, Phoenix, Arizona, USA.
Heinz-Josef LenzUniversity of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.ORCID 0000-0003-2178-9568
University of Southern California · USCaris Life Sciences (United States) · USGeorgetown University · USWayne State University · USInnsbruck Medical University · ATMayo Clinic · USUniversity of California, San Francisco · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USWest Virginia University · US
Funding
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MMember Site CoreU10CA180821 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Evanthia Galanis · 2014 to 2026
$177.3MSWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1MSWOG Statistics & Data Management Center complex - extension supplement for GY06U10CA180819 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Michael L. LeBlanc · 2014 to 2026
$115.2MStatistics CoreU10CA180882 · NCI · MAYO CLINIC ROCHESTER · PI Sumithra Jay Mandrekar · 2014 to 2026
$115.0MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5MNational Capital Area (NCA) NCI Community Oncology Research Program (NCORP)UG1CA239758 · NCI · GEORGETOWN UNIVERSITY · PI Lucile L. Adams-Campbell, Chiranjeev Dash · 2019 to 2026
$6.3MNCI National Clinical Trials Network – Network Lead Academic Participating SiteUG1CA233163 · NCI · WAYNE STATE UNIVERSITY · PI FLAHERTY, LAWRENCE E, SHIELDS, ANTHONY FRANK · 2019 to 2025
$3.5MUNC Lead Academic Participating SiteUG1CA233373 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CAREY, LISA A, DEES, ELIZABETH CLAIRE · 2019 to 2025
$3.5MNCI NIH HHS P01 CA196569NCI NIH HHS P30 CA014089NCI NIH HHS U10 CA180819NCI NIH HHS U10 CA180821NCI NIH HHS U10 CA180888NCI NIH HHS UG1 CA233163NCI NIH HHS UG1 CA233373NCI NIH HHS UG1 CA239758
Abstract
backgroundThe C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated with
methods7604 CRCs tested with NextGen Sequencing on DNA and RNA were analyzed. Molecular features were evaluated according to
results
conclusionsOur data show a strong association between
Indexed as
Colorectal NeoplasmsReceptors, ChemokineB7-H1 AntigenChemokine CCL5ChemokinesGene ExpressionHumansLigandsReceptors, CCR5Tumor MicroenvironmentB7-H1 AntigenCCL5 protein, humanCCR5 protein, humanChemokine CCL5ChemokinesLigandsReceptors, CCR5Receptors, ChemokineGastrointestinal NeoplasmsGene Expression ProfilingImmunotherapyMolecular Targeted TherapyTumor Biomarkers
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.