Evidence map›Paper›PMID 38212059›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2024

Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy.

Erik Kaestner, Alena Stasenko, Adam Schadler, Rebecca Roth, Kelsey Hewitt, Anny Reyes, Deqiang Qiu, Leonardo Bonilha, Natalie Voets, Ranliang Hu and 7 more

Open access · greenAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Erik KaestnerRadiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-3252-5365
Alena StasenkoRadiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Adam SchadlerRadiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Rebecca RothNeurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Kelsey HewittNeurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Anny ReyesRadiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA.
Deqiang QiuRadiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA.
Leonardo BonilhaDepartment of Neurology, University of South Carolina System, Columbia, South Carolina, USA.
Natalie VoetsNDCN, University of Oxford, Oxford, UK.ORCID 0000-0001-8078-4471
Ranliang HuRadiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA.
Jon WillieNeurosurgery, Washington University in St Louis, St Louis, Missouri, USA.
Nigel PedersenNeurology, UC Davis, Davis, California, USA.
Jerry ShihNeurosciences, University of California, San Diego, La Jolla, California, USA.
Sharona Ben-HaimNeurosurgery, University of California, San Diego, La Jolla, California, USA.
Robert GrossDepartment of Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Daniel DraneNeurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Carrie R McDonaldRadiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California, USA camcdonald@health.ucsd.edu.
Emory University · USUniversity of California San Diego · USUC San Diego Health System · USUniversity of California, Davis · USUniversity of Oxford · GBUniversity of South Carolina System · USWashington University in St. Louis · US

Funding

National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-makingR01NS124585 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2022 to 2025
$3.3M
Development of a personalized neurostimulation protocol for memory mapping in epilepsyK01NS124831 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAESTNER, ERIK JORDAN · 2022 to 2024
$339k
Improving language assessment in bilinguals with epilepsy using advanced neuroimaging and culturally-sensitive neuropsychological measuresF32NS119285 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STASENKO, ALENA · 2021 to 2023
$152k
NIMH NIH HHS R01 MH118514NIMH NIH HHS T32 MH018399NINDS NIH HHS F32 NS119285NINDS NIH HHS K01 NS124831NINDS NIH HHS R01 NS088748NINDS NIH HHS R01 NS124585
6 · The paper itself

Abstract

backgroundWith expanding neurosurgical options in epilepsy, it is important to characterise each options' risk for postoperative cognitive decline. Here, we characterise how patients' preoperative white matter (WM) networks relates to postoperative memory changes following different epilepsy surgeries.

methodsEighty-nine patients with temporal lobe epilepsy with T1-weighted and diffusion-weighted imaging as well as preoperative and postoperative verbal memory scores (prose recall) underwent either anterior temporal lobectomy (ATL: n=38) or stereotactic laser amygdalohippocampotomy (SLAH; n=51). We computed laterality indices (ie, asymmetry) for volume of the hippocampus and fractional anisotropy (FA) of two deep WM tracts (uncinate fasciculus (UF) and inferior longitudinal fasciculus (ILF)).

resultsPreoperatively, left-lateralised FA of the ILF was associated with higher prose recall (p<0.01). This pattern was not observed for the UF or hippocampus (ps>0.05). Postoperatively, right-lateralised FA of the UF was associated with less decline following left ATL (p<0.05) but not left SLAH (p>0.05), while right-lateralised hippocampal asymmetry was associated with less decline following both left ATL and SLAH (ps<0.05). After accounting for preoperative memory score, age of onset and hippocampal asymmetry, the association between UF and memory decline in left ATL remained significant (p<0.01).

conclusionsAsymmetry of the hippocampus is an important predictor of risk for memory decline following both surgeries. However, asymmetry of UF integrity, which is only severed during ATL, is an important predictor of memory decline after ATL only. As surgical procedures and pre-surgical mapping evolve, understanding the role of frontal-temporal WM in memory networks could help to guide more targeted surgical approaches to mitigate cognitive decline.

Indexed as

Epilepsy, Temporal LobeMemoryMemory DisordersNeurosurgical ProceduresPostoperative Cognitive ComplicationsWhite MatterAblation TechniquesAdultAmygdalaAnisotropyAnterior Temporal LobectomyDiffusion Magnetic Resonance ImagingFemaleFrontal LobeHippocampusHumansEPILEPSYEPILEPSY, SURGERYMEMORYMRI

Identifiers

PMID38212059
PMCPMC11187680
OpenAlexW4390738798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.