ArticleThe Journal of thoracic and cardiovascular surgery2024
Simulation-based design of bicuspidization of the aortic valve.
Article in The Journal of thoracic and cardiovascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects.Journal of cardiovascular translational research · 2026Pooled it
- Simulations predict improved valve performance without direct leaflet intervention after neonatal truncus arteriosus repair.The Journal of thoracic and cardiovascular surgery · 2026Article
- Does Intercommissural Distance Shortening in Bicuspid Aortic Valve Repair Improve Valve Opening Area?Annals of thoracic surgery short reports · 2026Article
- Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- Simulation-guided outlet valve repair: early integration of computationally-derived principles of free-edge length in bicuspidization repair.Frontiers in cardiovascular medicine · 2026Article
- Article
- Aortic valve repair using aortic wall as leaflet patch material in children.JTCVS techniques · 2025Article
- A fluid-structure interaction model of the zebrafish aortic valve.Journal of biomechanics · 2025Article
- Combined simulation and ex vivo assessment of free-edge length in bicuspidization repair for congenital aortic valve disease.JTCVS open · 2024Article
- Similar size formula for annulus, leaflet, and valsalva sinus in valve-sparing operations during bicuspid aortic valve repair.JTCVS open · 2024Article
- Effect of graft sizing in valve-sparing aortic root replacement for bicuspid aortic valve: The Goldilocks ratio.JTCVS techniques · 2024Article
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6 authors.
Funding
Abstract
objectiveSevere congenital aortic valve pathology in the growing patient remains a challenging clinical scenario. Bicuspidization of the diseased aortic valve has proven to be a promising repair technique with acceptable durability. However, most understanding of the procedure is empirical and retrospective. This work seeks to design the optimal gross morphology associated with surgical bicuspidization with simulations based on the hypothesis that modifications to the free edge length cause or relieve stenosis.
methodsModel bicuspid valves were constructed with varying free edge lengths and gross morphology. Fluid-structure interaction simulations were conducted in a single patient-specific model geometry. The models were evaluated for primary targets of stenosis and regurgitation. Secondary targets were assessed and included qualitative hemodynamics, geometric height, effective height, orifice area, and billow.
resultsStenosis decreased with increasing free edge length and was pronounced with free edge length less than or equal to 1.3 times the annular diameter d. With free edge length 1.5d or greater, no stenosis occurred. All models were free of regurgitation. Substantial billow occurred with free edge length 1.7d or greater.
conclusionsFree edge length 1.5d or greater was required to avoid aortic stenosis in simulations. Cases with free edge length 1.7d or greater showed excessive billow and other changes in gross morphology. Cases with free edge length 1.5d to 1.6d have a total free edge length approximately equal to the annular circumference and appeared optimal. These effects should be studied in vitro and in animal studies.
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