Evidence map›Paper›PMID 38211716›Full record

ArticleEnvironmental research2024

Gestational glyphosate exposure and early childhood neurodevelopment in a Puerto Rico birth cohort.

Haley M Jenkins, John D Meeker, Emily Zimmerman, Amber Cathey, Jennifer Fernandez, Gredia Huerta Montañez, Seonyoung Park, Zaira Rosario Pabón, Carmen M Vélez Vega, José F Cordero and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Haley M JenkinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address: hmjenkin@umich.edu.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address: meekerj@umich.edu.
Emily ZimmermanDepartment of Communication Sciences and Disorders, Northeastern University, Boston, MA, 02115, USA. Electronic address: e.zimmerman@northeastern.edu.
Amber CatheyDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address: acathey@umich.edu.
Jennifer FernandezDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address: jafernan@umich.edu.
Gredia Huerta MontañezDepartment of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA. Electronic address: grediamd@gmail.com.
Seonyoung ParkDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address: shnnpark@umich.edu.
Zaira Rosario PabónDepartment of Electrical and Computer Engineering, Northeastern University, Boston, MA, 02115, USA. Electronic address: z.rosariopabon@northeastern.edu.
Carmen M Vélez VegaDepartment of Social Sciences, UPR Medical Sciences Campus, University of Puerto Rico Graduate School of Public Health, San Juan, PR, 00936, USA. Electronic address: carmen.velez2@upr.edu.
José F CorderoDepartment of Epidemiology and Biostatistics, University of Georgia, Athens, GA, 30602, USA. Electronic address: jcordero@uga.edu.
Akram AlshawabkehDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, 02115, USA. Electronic address: a.alshawabkeh@northeastern.edu.
Deborah J WatkinsDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. Electronic address: debjwat@umich.edu.
University of Michigan · USNortheastern University · USUniversity of Georgia · USUniversity of Puerto Rico, Medical Sciences Campus · PR

Funding

Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI HARRIS, SEAN M · 2010 to 2024
$38.6M
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)UH3OD023251 · OD · NORTHEASTERN UNIVERSITY · PI Akram N Alshawabkeh · 2018 to 2026
$24.0M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
Toxicogenomics-based Mechanistic Multimedia Exposure Assessment and Child DevelopmentP50ES026049 · NIEHS · NORTHEASTERN UNIVERSITY · PI SUH, HELEN · 2015 to 2018
$3.6M
EPA R836155NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P42 ES017198NIEHS NIH HHS P50 ES026049NIEHS NIH HHS T32 ES007062NIH HHS UH3 OD023251
6 · The paper itself

Abstract

introductionN-(phosphonomethyl)glycine, or glyphosate, is a non-selective systemic herbicide widely used in agricultural, industrial, and residential settings since 1974. Glyphosate exposure has been inconsistently linked to neurotoxicity in animals, and studies of effects of gestational exposure among humans are scarce. In this study we investigated relationships between prenatal urinary glyphosate analytes and early childhood neurodevelopment.

methodsMother-child pairs from the PROTECT-CRECE birth cohort in Puerto Rico with measures for both maternal urinary glyphosate analytes and child neurodevelopment were included for analysis (n = 143). Spot urine samples were collected 1-3 times throughout pregnancy and analyzed for glyphosate and aminomethylphosphonic acid (AMPA), an environmental degradant of glyphosate. Child neurodevelopment was assessed at 6, 12, and 24 months using the Battelle Developmental Inventory, 2nd edition Spanish (BDI-2), which provides scores for adaptive, personal-social, communication, motor, and cognitive domains. We used multivariable linear regression to examine associations between the geometric mean of maternal urinary glyphosate analytes across pregnancy and BDI-2 scores at each follow-up. Results were expressed as percent change in BDI-2 score per interquartile range increase in exposure.

resultsPrenatal AMPA concentrations were negatively associated with communication domain at 12 months (%change = -5.32; 95%CI: 9.04, -1.61; p = 0.007), and communication subdomain scores at 12 and 24 months. At 24 months, four BDI-2 domains were associated with AMPA: adaptive (%change = -3.15; 95%CI: 6.05, -0.25; p = 0.038), personal-social (%change = -4.37; 95%CI: 7.48, -1.26; p = 0.008), communication (%change = -7.00; 95%CI: 11.75, -2.26; p = 0.005), and cognitive (%change = -4.02; 95%CI: 6.72, -1.32; p = 0.005). Similar trends were observed with GLY concentrations, but most confidence intervals include zero. We found no significant associations at 6 months.

conclusionsOur results suggest that gestational exposure to glyphosate is associated with adverse early neurodevelopment, with more pronounced delays at 24 months. Given glyphosate's wide usage, further investigation into the impact of gestational glyphosate exposure on neurodevelopment is warranted.

Indexed as

Birth CohortGlyphosatealpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidChild, PreschoolFemaleGlycineHumansPregnancyPuerto Ricoalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidGlycineGlyphosateAMPAChild developmentEnvironmental pollutantsGlyphosateHerbicideMaternal exposure

Identifiers

PMID38211716
PMCPMC12321046
OpenAlexW4390725433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.