Evidence map›Paper›PMID 38211712›Full record

ArticleGastroenterology2024

The FOXP3

Robyn Laura Kosinsky, Michelle M Gonzalez, Dominik Saul, Luísa Leite Barros, Mary R Sagstetter, Yaroslav Fedyshyn, Asha Nair, Zhifu Sun, Feda H Hamdan, Hunter R Gibbons and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. [Cimifugin ameliorates Crohn's disease-like colitis in mice by modulating Th-cell immune balanceNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Robyn Laura KosinskyDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.
Michelle M GonzalezDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Dominik SaulRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota; Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center, Tübingen, Germany.
Luísa Leite BarrosDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
Mary R SagstetterDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Yaroslav FedyshynDepartment of Physiology, Mayo Clinic, Rochester, Minnesota.
Asha NairDivision of Computational Biology, Mayo Clinic, Rochester, Minnesota.
Zhifu SunDivision of Computational Biology, Mayo Clinic, Rochester, Minnesota.
Feda H HamdanDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Hunter R GibbonsDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Mauricio E Perez PachonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Brooke R DrulinerDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
Steven A JohnsenRobert Bosch Center for Tumor Diseases, Stuttgart, Germany.
William A FaubionDivision of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona. Electronic address: Faubion.william@mayo.edu.
Mayo Clinic · USWinnMed · USMayo Clinic in Arizona · USRobert Bosch Hospital · DEUniversity of Tübingen · DE

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Tamas Ordog · 2009 to 2026
$22.2M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
MULTIDISCRIPLINARY TRAINING IN DIGESTIVE DISEASEST32DK007198 · NIDDK · MAYO CLINIC ROCHESTER · PI Harmeet Malhi · 1986 to 2026
$8.9M
KLF10 regulates colitis through mediating TGFb induction of FOXP3 in Treg cells.R01AI089714 · NIAID · MAYO CLINIC ROCHESTER · PI FAUBION, WILLIAM A · 2011 to 2025
$6.3M
Aging lymphocytes: senescence programs in lymphocytes relevant to human inflammatory bowel diseaseK08DK134759 · NIDDK · MAYO CLINIC ROCHESTER · PI Michelle M Gonzalez Salgado · 2023 to 2026
$654k
NCATS NIH HHS KL2 TR002379NIAID NIH HHS R01 AI089714NIDDK NIH HHS K08 DK134759NIDDK NIH HHS P30 DK084567NIDDK NIH HHS T32 DK007198
6 · The paper itself

Abstract

BACKGROUND &

aimsThe incidence of Crohn's disease (CD) continues to increase worldwide. The contribution of CD4

methodsWe performed single-cell RNA-sequencing in CD4

resultsWe identified 5 distinct FOXP3

conclusionsWe identified a novel, proinflammatory FOXP3

Indexed as

Crohn DiseaseForkhead Transcription FactorsHumansInflammationT-Lymphocytes, RegulatoryVorinostatForkhead Transcription FactorsFOXP3 protein, humanVorinostatIBDscRNA SequencingT Regulatory Cell

Identifiers

PMID38211712
PMCPMC10960691
OpenAlexW4390749170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.