ArticleCurrent biology : CB2024
The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish.
Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish.Nature communications · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026Review
- PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026Article
- Neural temporal scaling accounts for robust hunting behavior across temperatures.Nature communications · 2026Article
- Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain.Nature communications · 2026Article
- CaMPARI2 enables stimulus-locked whole-brain activity mapping at cellular resolution in unrestrained larval zebrafish.Frontiers in molecular neuroscience · 2026Article
- Linking brain and behavior states in Zebrafish Larvae locomotion using hidden Markov models.PLoS computational biology · 2026Article
- CaMPARI2 Enables Stimulus-Locked Whole-Brain Activity Mapping at Cellular Resolution in Unrestrained Larval Zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Behavioral and circuit principles of temperature gradient navigation.Current biology : CB · 2025Article
- Visual motion and landmark position align with heading direction in the zebrafish interpeduncular nucleus.Nature communications · 2025Article
- Learning to Navigate in Chemical Fields Without A Map at Low Reynolds Numbers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems.The Journal of comparative neurology · 2025Article
- Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making.bioRxiv : the preprint server for biology · 2025Article
- Sensorimotor integration enhances temperature stimulus processing.PLoS computational biology · 2025Article
- High throughput machine learning pipeline to characterize larval zebrafish motor behavior.PloS one · 2025Article
- Modeling of Charcot-Marie-Tooth disease in zebrafish.Frontiers in molecular neuroscience · 2025Review
- Whole-brain mapping in adult zebrafish and identification of a novel tank test functional connectome.bioRxiv : the preprint server for biology · 2024Article
- Vertebrate behavioral thermoregulation: knowledge and future directions.Neurophotonics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals must maintain physiological processes within an optimal temperature range despite changes in their environment. Through behavioral assays, whole-brain functional imaging, and neural ablations, we show that larval zebrafish, an ectothermic vertebrate, achieves thermoregulation through homeostatic navigation-non-directional and directional movements toward the temperature closest to its physiological setpoint. A brain-wide circuit encompassing several brain regions enables this behavior. We identified the preoptic area of the hypothalamus (PoA) as a key brain structure in triggering non-directional reorientation when thermal conditions are worsening. This result shows an evolutionary conserved role of the PoA as principal thermoregulator of the brain also in ectotherms. We further show that the habenula (Hb)-interpeduncular nucleus (IPN) circuit retains a short-term memory of the sensory history to support the generation of coherent directed movements even in the absence of continuous sensory cues. We finally provide evidence that this circuit may not be exclusive for temperature but may convey a more abstract representation of relative valence of physiologically meaningful stimuli regardless of their specific identity to enable homeostatic navigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.