ArticleCell host & microbe2024
Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway.
Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Retail wet markets, food handlers, and hospitalised patients as nodes in a shared non-typhoidal Salmonella ecosystem: a one health molecular epidemiological pilot study in Wuhan, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Host-microbiota-pathogen interactions drive Salmonella enterica serovar Typhimurium pathogenesis.Nature reviews. Microbiology · 2026Review
- Structure and function of Salmonella inner membrane.Archives of microbiology · 2026Review
- Unmasking pathogen traits for chronic colonization in neurogenic bladder.Cell reports · 2026Article
- Immune Responses to Phage Therapy in Humans: A Review.The Journal of infectious diseases · 2026Review
- Eosinophils enhance granuloma-mediated control of persistent Salmonella infection in mice.Nature microbiology · 2025Article
- Genetic diversity ofGut microbes · 2025Article
- Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection.FEMS microbiology reviews · 2025Review
- Establishment and epidemiological investigation of a dual fluorescent qPCR assay forFrontiers in cellular and infection microbiology · 2025Article
- Article
- Impact on Human Health ofInternational journal of molecular sciences · 2024Review
- From acute to persistent infection: revealing phylogenomic variations in Salmonella Agona.PLoS pathogens · 2024Article
- High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection.Nature genetics · 2024Article
- A genome-wide collection of barcoded single-gene deletion mutants in Salmonella enterica serovar Typhimurium.PloS one · 2024Article
- Within-host evolution of bacterial pathogens during persistent infection of humans.Current opinion in microbiology · 2022Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Several bacterial pathogens, including Salmonella enterica, can cause persistent infections in humans by mechanisms that are poorly understood. By comparing genomes of isolates longitudinally collected from 256 prolonged salmonellosis patients, we identified repeated mutations in global regulators, including the barA/sirA two-component regulatory system, across multiple patients and Salmonella serovars. Comparative RNA-seq analysis revealed that distinct mutations in barA/sirA led to diminished expression of Salmonella pathogenicity islands 1 and 4 genes, which are required for Salmonella invasion and enteritis. Moreover, barA/sirA mutants were attenuated in an acute salmonellosis mouse model and induced weaker transcription of host immune responses. In contrast, in a persistent infection mouse model, these mutants exhibited long-term colonization and prolonged shedding. Taken together, these findings suggest that selection of mutations in global virulence regulators facilitates persistent Salmonella infection in humans, by attenuating Salmonella virulence and inducing a weaker host inflammatory response.
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