ArticleScience (New York, N.Y.)2024
Deterministic reprogramming of neutrophils within tumors.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 251 papers.
0numbers the graph read from it
0cells of the map it votes in
251citing papers in PubMed
74.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
251 citing papers in PubMed, 309 citations in OpenAlex.
- Evaluation of Neutrophil to Lymphocyte Ratio in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma Treated With a Combination of Cetuximab and Nivolumab in a Phase II Clinical Trial.American journal of clinical oncology · 2026Trial
- Early neutrophil infiltration promotes TRIMELVax-induced antitumor immunity by linking local inflammation to tumor control.Oncoimmunology · 2026Article
- IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells.Oncoimmunology · 2026Review
- Dynamic single-cell landscape reveals a T-cell-suppressed microenvironment and a conserved neutrophil program in the lung metastatic niche.Genes & diseases · 2026Article
- CD8+ regulatory T cells shorten neutrophil lifespan to reduce hemorrhagic transformation after ischemic stroke.The Journal of clinical investigation · 2026Article
- IGF2BP2 remodels the lung metastatic immune microenvironment to promote bladder cancer metastasis.Cellular & molecular immunology · 2026Article
- Intestinal epithelial GSK3β governs fumarate-dependent neutrophil reprogramming to promote colorectal cancer.Nature cancer · 2026Article
- Neutrophil-driven immunosuppression in cancer.Cell insight · 2026Review
- Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis.Cancer discovery · 2026Article
- CAR-engineered neutrophils derived from induced pluripotent stem cells: a new frontier in cellular immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Bone Marrow Microenvironment Drives Mature Neutrophil to a CD83International journal of cancer · 2026Article
- Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Neutrophils in cancer.Nature reviews. Cancer · 2026Review
- Long-Term Impact of Historical BCG Vaccination Policies on Parkinson's Disease Risk: A Hypothesis-Generating Retrospective Cohort Analysis.Biomedicines · 2026Article
- Φ-Space ST: A platform-agnostic method to identify cell states in spatial transcriptomics studies.Cell reports methods · 2026Article
- Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies.Molecular cancer · 2026Review
- A Nutrient-Sensitive ZRF1-Dependent Secretory Network Involving S100A9 Contributes to Neutrophil Plasticity in Triple-Negative Breast Cancer.ACS pharmacology & translational science · 2026Article
- Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity.Science advances · 2026Article
- CAFs shape the immunosuppressive microenvironment of pancreatic cancer through the Lin28b-STING Axis.Nature communications · 2026Article
- GM-CSF Promotes Neutrophil PD-L1 Expression Through the VEGFR-2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
191 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
43 authors at 12 institutions in 7 countries.
Melissa S F Ng *Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0003-3826-2746
Immanuel Kwok *Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0003-1523-1621
Leonard Tan *Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-6923-1021
Changming Shi *Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-1111-0283
Daniela Cerezo-WallisArea of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
Yingrou TanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0003-3563-6546
Keith LeongSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-0568-3387
Gabriel F CalvoDepartment of Mathematics & MOLAB-Mathematical Oncology Laboratory, University of Castilla-La Mancha, Ciudad Real, Spain.ORCID 0000-0002-3623-236X
Katharine YangSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-8209-1289
Yuning ZhangImmunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jingsi JinShanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ka Hang LiongSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-7575-032X
Dandan WuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rui HeShanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dehua LiuSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-7633-9006
Ye Chean TehSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0003-0155-2109
Camille BleriotINSERM U1015, Institut Gustave Roussy, Villejuif, France.ORCID 0000-0002-4298-2888
Nicoletta CaronniGenomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-3263-7108
Zhaoyuan LiuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-3117-0833
Kaibo DuanSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Vipin NarangSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Iván BallesterosArea of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID 0000-0002-6246-2353
Federica MoalliDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Mengwei LiSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
Jinmiao ChenSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0001-7547-6423
Yao LiuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.ORCID 0000-0003-0365-3229
Lianxin LiuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.ORCID 0000-0002-3535-6467
Jingjing QiDepartment of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0003-3665-3978
Yingbin LiuDepartment of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lingxi JiangDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-6037-6972
Baiyong ShenDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-3994-248X
Hui ChengState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.ORCID 0000-0002-1988-6572
Tao ChengState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.ORCID 0000-0002-5925-2769
Veronique AngeliImmunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID 0000-0002-2759-3497
Ankur SharmaHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, Western Australia, Australia.ORCID 0000-0002-6862-136X
Yuin-Han LohInstitute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore.ORCID 0000-0002-4715-6454
Hong Liang TeyNational Skin Centre, National Healthcare Group, Singapore.ORCID 0000-0001-8894-6711
Shu Zhen ChongSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-2682-912X
Matteo IannaconeDivision of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-9370-2671
Renato OstuniGenomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-0460-3426
Andrés HidalgoArea of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.ORCID 0000-0001-5513-555X
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0002-2857-7755
Lai Guan NgSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.ORCID 0000-0003-1905-3586
Agency for Science, Technology and Research · SGShanghai Jiao Tong University · CNInstituto de Salud Carlos III · ESUniversity of Science and Technology of China · CNVita-Salute San Raffaele University · ITChinese Academy of Medical Sciences & Peking Union Medical College · CNNational University of Singapore · SGCentre National de la Recherche Scientifique · FRCurtin University · AUNational Skin Centre · SGThe San Raffaele Telethon Institute for Gene Therapy · ITUniversity of Castilla-La Mancha · ES
Funding
Non-canonical functions of neutrophilsR01AI165661 · NIAID · YALE UNIVERSITY · PI HIDALGO, ANDRES · 2022 to 2025
$2.8MNIAID NIH HHS R01 AI165661
Abstract
Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1
Indexed as
Cellular ReprogrammingNeoplasmsNeovascularization, PathologicNeutrophilsEpigenesis, GeneticHumansHypoxiaProteomicsReceptors, TNF-Related Apoptosis-Inducing LigandTranscription, GeneticReceptors, TNF-Related Apoptosis-Inducing Ligand
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.