Evidence map›Paper›PMID 38206814›Full record

ArticleCell reports2024

TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet.

Sarah M Graff, Arya Y Nakhe, Prasanna K Dadi, Matthew T Dickerson, Jordyn R Dobson, Karolina E Zaborska, Chloe E Ibsen, Regan B Butterworth, Nicholas C Vierra, David A Jacobson

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The diabetes-associated KDiabetologia · 2026
    Article
  3. Review
  4. Review
  5. Mitochondria-associated programmed cell death in pancreatic β cell of T2DM.Apoptosis : an international journal on programmed cell death · 2026
    Review
  6. Sarco/Endoplasmic Reticulum CaJournal of the American Heart Association · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sarah M GraffDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University, Nashville, TN 37204, USA.
Arya Y NakheDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Jordyn R DobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Karolina E ZaborskaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Chloe E IbsenDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Regan B ButterworthDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Nicholas C VierraDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: david.a.jacobson@vanderbilt.edu.
Vanderbilt University · USLipscomb University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
MULTIDISCIPLINARY TRAINING IN MOLECULAR ENDOCRINOLOGYT32DK007563 · NIDDK · VANDERBILT UNIVERSITY · PI Richard M O'Brien · 1988 to 2026
$15.9M
Initiative for Maximizing Student Development (IMSD) at VanderbiltT32GM139800 · NIGMS · VANDERBILT UNIVERSITY · PI RHOADES (STERLING), JULIE A, SEREZANI, C. HENRIQUE · 2021 to 2025
$3.7M
Two-Pore-Domain Potassium Channels as Novel Targets for Modulating Islet Hormone SecretionR01DK097392 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2013 to 2022
$3.3M
Molecular Mechanisms Regulating Pancreatic Delta Cell Function and DysfunctionR01DK129340 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2022 to 2026
$2.3M
Secretagogue and Gi/o-GPCR signaling through the islet Na+/K+-ATPase in health and diabetesR01DK136768 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2023 to 2026
$2.0M
Designing selective TALK-1 inhibitors to reduce beta-cell dysfunction in diabetesR01DK115620 · NIDDK · VANDERBILT UNIVERSITY · PI JACOBSON, DAVID AARON · 2018 to 2021
$1.6M
The role of endoplasmic reticulum (ER) localized TALK-1 channels in beta-cell insulin secretion, mitochondrial function and the ER stress responseF31DK118855 · NIDDK · VANDERBILT UNIVERSITY · PI GRAFF, SARAH MILIAN · 2018 to 2020
$64k
TALK-1 channels as a novel target to modulate basal insulin secretion and obesityF31DK109625 · NIDDK · VANDERBILT UNIVERSITY · PI VIERRA, NICHOLAS CATIN · 2016 to 2017
$42k
NCI NIH HHS P30 CA068485NIDDK NIH HHS F31 DK109625NIDDK NIH HHS F31 DK118855NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK097392NIDDK NIH HHS R01 DK115620NIDDK NIH HHS R01 DK129340NIDDK NIH HHS R01 DK136768NIDDK NIH HHS T32 DK007563NIGMS NIH HHS T32 GM139800
6 · The paper itself

Abstract

Mitochondrial Ca

Indexed as

Diabetes MellitusInsulin-Secreting CellsAdenosine TriphosphateAnimalsCalciumDietEndoplasmic ReticulumGlucoseHomeostasisInsulinInsulin SecretionMiceMice, KnockoutMitochondriaPotassium Channels, Tandem Pore DomainAdenosine TriphosphateCalciumGlucoseInsulinKcnk16 protein, mousePotassium Channels, Tandem Pore Domaincalcium handlingCP: Cell biologyCP: Metabolismdiabetesendoplasmic reticuluminsulin secretionK2Pmetabolismmitochondriapancreatic β-cellTALK-1two-pore-domain potassium channel

Identifiers

PMID38206814
PMCPMC10961926
OpenAlexW4390708560

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.