ArticleBlood advances2024
Managing sickle cell disease and related complications in pregnancy: results of an international Delphi panel.
Article in Blood advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Comment on: Managing sickle cell disease and related complications in pregnancy: results of an international Delphi panel.BMC pregnancy and childbirth · 2026Article
- Navigating pregnancy, postpartum care and reproductive autonomy with sickle cell disease in Uganda: an interpretive phenomenological study in Eastern and Central Uganda.Research square · 2026Article
- LEARNER - A prospective, randomized controlled study to evaluate the effects of daily low dose aspirin in pregnant women with sickle cell disease when initiated at the first trimester versus the second trimester of the gestational period - study protocol.Contemporary clinical trials communications · 2026Article
- "Heartbreak and Frustration'' experiences of healthcare providers caring for pregnant women with sickle cell disease in Uganda.PloS one · 2026Article
- Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025Review
- Emerging pathways in thromboinflammation of sickle cell disease: novel findings in disease pathogenesis.Research and practice in thrombosis and haemostasis · 2025Review
- Exploring perspectives on skull base chordoma management: a modified Delphi approach to consensus.Journal of neuro-oncology · 2025Article
- Safety of prostaglandins in the peripartum period in case of sickle-cell disease: A multicenter cohort study.Pregnancy (Hoboken, N.J.) · 2025Article
- Knowledge, Confidence, and Comfort Regarding Sickle Cell Disease Among Medical Students: A Pilot Study in Two Universities.Healthcare (Basel, Switzerland) · 2025Article
- Hyperhemolysis in a sickle cell disease patient in pregnancy.Annals of hematology · 2025Article
- Antenatal medication management for women with sickle-cell disease: A systematic review.Pregnancy (Hoboken, N.J.) · 2025Review
- Risk factors for immediate postpartum sickle cell disease-specific maternal morbidity.British journal of haematology · 2025Article
- Position Paper on the Management of Sickle Cell Disease in Saudi Arabia: Understanding Disease Landscape, Identifying Challenges, and Exploring Opportunities in Transfusion Therapies.Journal of clinical medicine · 2025Review
- Effect of Homozygous Sickle Cell Anemia on Perinatal Outcomes: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Thalassemias and Sickle Cell Diseases in Pregnancy: SITE Good Practice.Journal of clinical medicine · 2025Article
- Quality of life in people with sickle cell disease treated with automated red blood cell exchange.Vox sanguinis · 2025Review
- Sickle cell disease and infertility risks: implications for counseling and care of affected girls and women.Expert review of hematology · 2024Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractData to guide evidence-based management of pregnant people with sickle cell disease (SCD) are limited. This international Delphi panel aimed to identify consensus among multidisciplinary experts for SCD management during pregnancy. The 2-round Delphi process used questionnaires exploring 7 topics (antenatal care, hydroxyurea use, transfusion, prevention of complications, treatment of complications, delivery and follow-up, and bottlenecks and knowledge gaps) developed by a steering committee. Thirteen panelists (hematologists, physiologists, obstetricians, maternal fetal medicine, and transfusion medicine physicians) from the United States, the United Kingdom, Turkey, and France completed the first survey; 12 panelists completed the second round. Anonymized responses were collected and summarized by a contract research organization (Akkodis Belgium). Consensus and strong consensus were predefined as 75% to 90% (9-10 of 12) and >90% (≥11 of 12) of panelists, respectively, agreeing or disagreeing on a response to a predefined clinical scenario or statement. In several areas of SCD management, consensus was achieved: experts recommended performing at least monthly multidisciplinary antenatal follow-up, administering prophylactic aspirin for preeclampsia prevention between gestational weeks 12 and 36, initiating prophylactic transfusion therapy in certain cases, or choosing automated red blood cell exchange over other transfusion methods for patients with iron overload or severe acute chest syndrome. No consensus was reached on several topics including the prophylactic aspirin dose, indications for starting infection prophylaxis, routine use of prophylactic transfusions, or use of prophylactic transfusions for preventing fetal complications. These recommendations could inform clinical care for patients with SCD who are pregnant in the absence of large clinical trials involving this population; the identified knowledge gaps can orient future research.
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