Evidence map›Paper›PMID 38206528›Full record

ArticleMolecular biotechnology2024

Curcumin Promotes Diabetic Foot Ulcer Wound Healing by Inhibiting miR-152-3p and Activating the FBN1/TGF-β Pathway.

Mei Cao, Zhisheng Duan, Xianting Wang, Pan Gong, Limei Zhang, Bin Ruan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  3. Chemical constituents in the rhizome of Curcuma longa and the pharmacological importance of curcumin hybrids.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mei Cao *Endocrinology Department, The Third People's Hospital of Yunnan Province, Kunming, 650011, Yunnan, China.
Zhisheng Duan *Endocrinology Department, The Third People's Hospital of Yunnan Province, Kunming, 650011, Yunnan, China.
Xianting WangEndocrinology Department, Clinical Medical College of Dali University, Dali, 671000, Yunnan, China.
Pan GongEndocrinology Department, Clinical Medical College of Dali University, Dali, 671000, Yunnan, China.
Limei ZhangEndocrinology Department, Clinical Medical College of Dali University, Dali, 671000, Yunnan, China.
Bin RuanOccupational Diseases Department, The Third People's Hospital of Yunnan Province, No. 292 Beijing Road, Guandu District, Kunming, 650011, Yunnan, China. ruanbin7@sohu.com.ORCID http://orcid.org/0009-0009-5518-0495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to investigate the mechanism of curcumin in diabetic foot ulcer (DFU) wound healing. A DFU rat model was established, and fibroblasts were cultured in a high-glucose (HG) environment to create a cell model. Various techniques, including Western blot, RT‒qPCR, flow cytometry, Transwell, cell scratch test and H&E staining, were employed to measure the levels of relevant genes and proteins, as well as to assess cell proliferation, apoptosis, migration, and pathological changes. The results showed that miR-152-3p was overexpressed in DFU patients, while FBN1 was underexpressed. Curcumin was found to inhibit fibroblast apoptosis, promote proliferation, migration, and angiogenesis in DFU rats, and accelerate wound healing in DFU rats. In addition, overexpression of miR-152-3p weakened the therapeutic effect of curcumin, while overexpression of FBN1 reversed the effects of the miR-152-3p mimic. Further investigations into the underlying mechanisms revealed that curcumin expedited wound healing in DFU rats by restoring the FBN1/TGF-β pathway through the inhibition of miR-152-3p. In conclusion, curcumin can suppress the activity of miR-152-3p, which, in turn, leads to the rejuvenation of the FBN1/TGF-β pathway and accelerates DFU wound healing.

Indexed as

CurcuminDiabetic FootMicroRNAsSignal TransductionWound HealingAdipokinesAnimalsApoptosisCell MovementCell ProliferationDisease Models, AnimalFemaleFibrillin-1FibroblastsHumansMaleAdipokinesCurcuminFBN1 protein, humanFibrillin-1MicroRNAsTransforming Growth Factor betaCurcuminDiabetic foot ulcerFBN1miR-152-3pTGF-β

Identifiers

PMID38206528
PMCPMC11087368

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.