Evidence map›Paper›PMID 38206492›Full record

ArticleJournal of medical ultrasonics (2001)2024

Assessment of renal congestion in a rat model with congestive heart failure using superb microvascular imaging.

Tomofumi Nakatsukasa, Tomoko Ishizu, Ruriko Hayakawa, Masumi Ouchi, Naoto Kawamatsu, Kimi Sato, Masayoshi Yamamoto, Tomoko Machino-Ohtsuka, Kunio Kawanishi, Yoshihiro Seo

Erratum issuedAbstract read
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In one paragraph

Article in Journal of medical ultrasonics (2001), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Tomofumi NakatsukasaDepartment of Cardiology, Institute of Medicine, University of Tsu Kuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Tomoko IshizuDepartment of Cardiology, Institute of Medicine, University of Tsu Kuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. tomoco@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0003-3794-899X
Ruriko HayakawaDepartment of Medical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Masumi OuchiDepartment of Medical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Naoto KawamatsuDepartment of Cardiology, Institute of Medicine, University of Tsu Kuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Kimi SatoDepartment of Cardiology, Institute of Medicine, University of Tsu Kuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Masayoshi YamamotoDepartment of Cardiology, Institute of Medicine, University of Tsu Kuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Tomoko Machino-OhtsukaDepartment of Cardiology, Institute of Medicine, University of Tsu Kuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Kunio KawanishiDepartment of Experimental Pathology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yoshihiro SeoDepartment of Cardiology, Faculty of Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Funding

the Operational Expense Grant of University of Tsukuba 10100
6 · The paper itself

Abstract

purposeRenal congestion is a therapeutic target in congestive heart failure. However, its detailed evaluation in a clinical setting is challenging. This study sought to assess renal congestion impairment using superb microvascular imaging (SMI), a simple and accessible method.

methodsDahl salt-sensitive rats, used as a model for congestive heart failure, underwent central venous pressure (CVP) measurements. Renal congestion was evaluated through measurements of renal medullary pressure (RMP) and assessment of renal perfusion using contrast-enhanced ultrasonography at both the early (control group) and heart failure phases (HF group). All rats were assessed with SMI. The region of interest (ROI) was set in interlobular vessels, interlobar vessels, and a combination of these areas. The area ratio was calculated from the color pixel count in the ROI divided by the total pixel count in the ROI. Intrarenal perfusion index (IRPI) was defined as (maximum area ratio-minimum area ratio) / maximum area ratio.

resultsThere were no significant differences in renal function and left ventricular ejection fraction between the two groups. CVP, time-to-peak (TTP) in the medulla, and RMP were higher in the HF group than in the control group. In the HF group, IRPI, evaluated in the interlobular vessels, was significantly higher than in the control group. IRPI was positively correlated with TTP in the medulla (p = 0.028, R = 0.60) and RMP (p < 0.001, R = 0.84), indicating that IRPI reflected renal congestion.

conclusionsIRPI is a useful tool for assessing renal congestion in rats with congestive heart failure.

Indexed as

Disease Models, AnimalHeart FailureKidneyRats, Inbred DahlAnimalsContrast MediaKidney DiseasesMaleMicrovesselsRatsRenal CirculationUltrasonographyContrast MediaCongestive heart failureRenal congestionSuperb microvascular imaging

Identifiers

PMID38206492
PMCPMC11928411

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.