ETV6::NTRK3-associated papillary adenocarcinoma: let us play it by ear.

Diana Bell, Ellie Maghami, Rania Bakkar, Michelle Afkhami

Abstract readCase Reports

In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Diana BellDepartments of Anatomic Pathology, City of Hope Cancer Center, Duarte, CA, 91010, USA. dbell@coh.org.

Ellie MaghamiHead and Neck Surgery, City of Hope Cancer Center, Duarte, CA, 91010, USA.

Rania BakkarDepartments of Anatomic Pathology, City of Hope Cancer Center, Duarte, CA, 91010, USA.

Michelle AfkhamiDepartments of Anatomic Pathology, City of Hope Cancer Center, Duarte, CA, 91010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceruminous glands are modified apocrine glands, situated in the external auditory canal (EAC) that, together with sebaceous glands, produce cerumen. The neoplastic transformation of these structures is exceedingly rare. We encounter two cases of EAC adenocarcinoma with ETV6::NTRK3 fusion. Despite this genetic overlap, the morphology and immunophenotype delineate its clear separation from secretory carcinoma. These cases demonstrate novel primary EAC adenocarcinoma with papillary morphology, which expands the ever-increasing list of ETV6::NTRK3-positive malignancies and which we would like to term ETV6::NTRK3-translocation associated papillary adenocarcinoma. We also advocate the use of molecular techniques in rare tumors of uncertain type or differentiation, to increase understanding and possibilities of reproducible classification of these rare neoplasms. Pathologists and oncologists should recognize this entity, which leads to a direct approach for detecting NTRK fusion for appropriate treatment.

Indexed as

Adenocarcinoma, PapillaryOncogene Proteins, FusionAgedBiomarkers, TumorEar CanalEar NeoplasmsETS Translocation Variant 6 ProteinFemaleHumansMaleMiddle AgedProto-Oncogene Proteins c-etsReceptor, trkCRepressor ProteinsBiomarkers, TumorETS Translocation Variant 6 ProteinETV6-NTRK3 fusion protein, humanOncogene Proteins, FusionProto-Oncogene Proteins c-etsReceptor, trkCRepressor ProteinsCeruminous glandsETV6::NTRK3External ear canalPapillary adenocarcinoma

Identifiers

PMID38206384

DOI10.1007/s00428-024-03735-6

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.