Evidence map›Paper›PMID 38206355›Full record

ArticleSkeletal radiology2024

Thigh muscle and fat volumes are associated with knee cartilage abnormalities and bone marrow edema-like lesions: data from the osteoarthritis initiative.

Rawee Manatrakul, Amir M Pirmoazen, Upasana U Bharadwaj, Zehra Akkaya, Paula J Giesler, John A Lynch, Michael C Nevitt, Charles E McCulloch, Gabby B Joseph, Thomas M Link

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Intramuscular Fat Infiltration and Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Rawee ManatrakulDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA. Rmanatrakul@gmail.com.ORCID http://orcid.org/0009-0003-1133-3847
Amir M PirmoazenDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Upasana U BharadwajDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Zehra AkkayaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Paula J GieslerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
John A LynchDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Gabby B JosephDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
University of California, San Francisco · USUniversity of Freiburg · DE

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
Understanding the mechanisms by which weight change affects progression of knee osteoarthritis in obese and overweight individuals: An analysis of the Osteoarthritis Initiative DatasetR01AR078917 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GABRIELLE JOSEPH, THOMAS M LINK · 2021 to 2026
$3.4M
UCSF Musculoskeletal Training ProgramT32AR080618 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aaron J Fields · 2023 to 2026
$978k
NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R01 AR078917NIAMS NIH HHS R01-AR078917NIAMS NIH HHS T32 AR080618NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

objectiveTo investigate the associations of thigh muscle and fat volumes with structural abnormalities on MRI related to knee osteoarthritis. MATERIALS AND

methodsMRI studies of the thighs and knees from 100 individuals were randomly selected from the Osteoarthritis Initiative Cohort. Whole Organ MR Scoring (WORMS) and effusion-synovitis scoring were performed in all knee MRI. Thigh muscles, intermuscular fat, and subcutaneous fat were manually segmented in 15 consecutive MR thigh images. Radiographic Kellgren-Lawrence grades (KLG) were also obtained in all knee radiographs. Independent t-tests were used to investigate the associations between thigh muscle and fat volumes, and sex. Mixed-effects analyses were obtained to investigate the associations between thigh muscle and fat volumes, KLG, WOMAC pain score, cartilage and bone marrow WORMS, as well as effusion-synovitis scores.

resultsWomen had higher subcutaneous fat volume than men (616.82 vs. 229.13 cm

conclusionIncreased quadriceps and hamstring volumes were negatively associated with cartilage lesion and BMEL scores while no evidence of an association was found between thigh muscle and fat volumes, and radiographic knee osteoarthritis or effusion-synovitis grading.

Indexed as

EdemaMagnetic Resonance ImagingOsteoarthritis, KneeThighAdipose TissueAgedBone MarrowCartilage, ArticularFemaleHumansMaleMiddle AgedMuscle, SkeletalFat volumeHamstringKnee osteoarthritisMuscle volumeQuadriceps

Identifiers

PMID38206355
PMCPMC11096053
OpenAlexW4390743566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.