Evidence map›Paper›PMID 38206293›Full record

ArticleAging2024

An endoplasmic reticulum stress-related signature featuring ASNS for predicting prognosis and immune landscape in prostate cancer.

Zhenyu Wu, Zhenquan Wu, Jie Zeng, Yaxuan Liu, Yue Wang, Huixin Li, Taolin Xia, Weitao Liu, Zhe Lin, Wenfeng Xu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zhenyu WuDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
Zhenquan WuDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
Jie ZengDepartment of Thoracic Surgery, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, P.R. China.
Yaxuan LiuDepartment of Blood Transfusion, Shenzhen Hospital Affiliated to Southern Medical University, Shenzhen, P.R. China.
Yue WangThe First Clinical Medical College, Guangdong Medical University, Zhanjiang, P.R. China.
Huixin LiDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
Taolin XiaDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
Weitao LiuDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
Zhe LinDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
Wenfeng XuDepartment of Urology, The First People’s Hospital of Foshan, Foshan, P.R. China.
First People's Hospital of Foshan · CNGuangdong Medical College · CNGuangzhou Medical University · CNSouthern Medical University Shenzhen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PRAD) is one of the common malignant tumors of the urinary system. In order to predict the treatment results for PRAD patients, this study proposes to develop a risk profile based on endoplasmic reticulum stress (ERS). Based on the Memorial Sloan-Kettering Cancer Center (MSKCC) cohort and the Gene Expression Omnibus database (GSE70769), we verified the predictive signature. Using a random survival forest analysis, prognostically significant ERS-related genes were found. An ERS-related risk score (ERscore) was created using multivariable Cox analysis. In addition, the biological functions, genetic mutations and immune landscape related to ERscore are also studied to reveal the underlying mechanisms related to ERS in PRAD. We further explored the ERscore-related mechanisms by profiling a single-cell RNA sequencing (scRNA-seq) dataset (GSE137829) and explored the oncogenic role of ASNS in PRAD through

Indexed as

Prostatic NeoplasmsCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCarcinogenesisCarcinogensEndoplasmic Reticulum StressHumansMalePrognosisASNS protein, humanCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCarcinogensASNSERSgene signatureprostate cancerTCGA

Identifiers

PMID38206293
PMCPMC10817364
OpenAlexW4390705330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.