Evidence map›Paper›PMID 38206279›Full record

ArticleAlcohol, clinical & experimental research2024

Latent profiles of regulatory flexibility in alcohol use disorder: Associations with delay discounting and symptoms of depression, anxiety, and stress.

Candice L Dwyer, William H Craft, Devin C Tomlinson, Allison N Tegge, Jungmeen Kim-Spoon, Warren K Bickel

Abstract read
In one paragraph

Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Candice L DwyerFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.
William H CraftFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.
Devin C TomlinsonFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.
Allison N TeggeDepartment of Statistics, Virginia Tech, Blacksburg, Virginia, USA.
Jungmeen Kim-SpoonDepartment of Psychology, Virginia Tech, Blacksburg, Virginia, USA.
Warren K BickelFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA.ORCID https://orcid.org/0000-0002-1048-7372

Funding

Testing Reinforcer Pathology: Mechanisms and Interventions to Change Alcohol ValuationR01AA027381 · NIAAA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LACONTE, STEPHEN M · 2019 to 2023
$3.5M
NIAAA NIH HHS R01 AA027381NIAAA NIH HHS R01AA027381
6 · The paper itself

Abstract

backgroundRegulatory flexibility (RF) involves three distinct components of self-regulation: context sensitivity, repertoire, and feedback responsiveness. Subgroups based on differences in RF have been identified in a general sample and are differentially associated with symptoms of anxiety and depression. However, potential RF profiles have not been examined in individuals with substance use disorders. This study examined RF subtypes in individuals with alcohol use disorder (AUD) and their associations with psychosocial outcomes (i.e., depression, anxiety, and stress) and delay discounting (a core feature of addiction).

methodsIndividuals (n = 200) with an Alcohol Use Disorders Identification Test score of >16 (mean = 24.12 (±6.92)) were recruited from Amazon Mechanical Turk (mean = 37.26 years old (±11.41); 94 (47%) women). Participants completed the Context Sensitivity Index, the Flexible Regulation of Emotional Expression Scale, and the Coping Flexibility Scale to assess RF. Participants also completed an Adjusting Amount Delay Discounting Task and the Depression, Anxiety, and Stress Scale (DASS-21). Latent profile analyses (LPA) were used to identify patterns in RF deficits. Kruskal-Wallis and Dunn's tests were performed to examine differences in discounting rates and symptoms of depression, anxiety, and stress across RF profiles.

resultsThe LPA revealed a 2-profile characterization, including (1) context sensitive regulators (CSR; n = 39) and (2) moderate flexibility regulators (MFR; n = 161). CSR demonstrated significantly lower symptoms of depression (p = 0.004), anxiety (p < 0.001), and stress (p < 0.001) than MFR. CSR also displayed significantly lower AUDIT scores (p = 0.031).

conclusionsFindings illustrate that among individuals with moderate-severe AUD, those high in context sensitivity coupled with moderate abilities in repertoire and feedback responsiveness have fewer symptoms of depression, anxiety, and stress. Together, context sensitivity may be an important and protective component of RF among individuals with AUD.

Indexed as

alcohol use disorderdelay discountingemotion regulationregulatory flexibility

Identifiers

PMID38206279
PMCPMC10786339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.