Evidence map›Paper›PMID 38206111›Full record

ArticleBiochemistry2024

Coevolutionary Information Captures Catalytic Functions and Reveals Divergent Roles of Terpene Synthase Interdomain Connections.

Charisse M Nartey, Hyun Jo Koo, Caroline Laurendon, Hana Z Shaik, Paul O'maille, Joseph P Noel, Faruck Morcos

Open access · hybridAbstract read
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Charisse M NarteyDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0001-5275-366X
Hyun Jo KooHoward Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.
Caroline LaurendonJohn Innes Centre, Department of Metabolic Biology, Norwich Research Park, Norwich NR4 7UH, U.K.
Hana Z ShaikDepartment of Bioengineering, The University of Texas at Dallas, Richardson, Texas 75080, United States.
Paul O'mailleJohn Innes Centre, Institute of Food Research, Food & Health Programme, Norwich Research Park, Norwich NR4 7UA, U.K.
Joseph P NoelHoward Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-1277-0331
Faruck MorcosDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0001-6208-1561
The University of Texas at Dallas · USNorwich Research Park · GBSalk Institute for Biological Studies · US

Funding

Computational Tools to Characterize the Effects of Protein and RNA Variability in Function and InteractionsR35GM133631 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Alonso Faruck Morcos · 2019 to 2026
$3.0M
NIGMS NIH HHS R35 GM133631
6 · The paper itself

Abstract

Inferring the historical and biophysical causes of diversity within protein families is a complex puzzle. A key to unraveling this problem is characterizing the rugged topography of sequence-function adaptive landscapes. Using biochemical data from a 2

Indexed as

Alkyl and Aryl TransferasesCatalysisCatalytic DomainMutationAlkyl and Aryl Transferasesterpene synthase

Identifiers

PMID38206111
PMCPMC10851433
OpenAlexW4390743229

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.