Evidence map›Paper›PMID 38206030›Full record

ArticleMicrobiology spectrum2024

Gold(I) ion and the phosphine ligand are necessary for the anti-

C I Ma, J A Tirtorahardjo, S S Schweizer, J Zhang, Z Fang, L Xing, M Xu, D A Herman, M T Kleinman, B S McCullough and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

C I MaDepartment of Medicine, Division of Infectious Diseases, University of California at Irvine, Irvine, California, USA.
J A TirtorahardjoDepartment of Microbiology and Molecular Genetics, University of California at Irvine, Irvine, California, USA.
S S SchweizerSchool of Biological Sciences; University of California at Irvine, Irvine, California, USA.
J ZhangSchool of Biological Sciences; University of California at Irvine, Irvine, California, USA.
Z FangSchool of Biological Sciences; University of California at Irvine, Irvine, California, USA.
L XingIrvine Materials Research Institute; University of California at Irvine, Irvine, California, USA.
M XuIrvine Materials Research Institute; University of California at Irvine, Irvine, California, USA.
D A HermanDepartment of Medicine, Occupational and Environmental Medicine, University of California at Irvine, Irvine, California, USA.
M T KleinmanDepartment of Medicine, Occupational and Environmental Medicine, University of California at Irvine, Irvine, California, USA.
B S McCulloughDepartment of Medicinal Chemistry, University of Utah College of Pharmacy, Salt Lake City, Utah, USA.
A M BarriosDepartment of Medicinal Chemistry, University of Utah College of Pharmacy, Salt Lake City, Utah, USA.
R M AndradeDepartment of Medicine, Division of Infectious Diseases, University of California at Irvine, Irvine, California, USA.ORCID 0000-0002-8802-1118

Funding

Thio-dependent Antioxidants: A Novel Drug Target for Toxoplasma GondiiK08AI102989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDRADE, ROSA M. · 2014 to 2018
$965k
NIAID NIH HHS K08 AI102989
6 · The paper itself

Abstract

Auranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising antiparasitic medication in recent years. The gold(I) ion in auranofin is postulated to be responsible for its antiparasitic activity. Notably

Indexed as

Arthritis, RheumatoidPhosphinesToxoplasmaToxoplasmosisAntiparasitic AgentsAuranofinAurothioglucoseGoldGold Sodium ThiomalateHumansLigandsAntiparasitic AgentsAuranofinAurothioglucoseGoldGold Sodium ThiomalateLigandsphosphinePhosphinesauranofindrug discoverygoldrepurposingToxoplasma

Identifiers

PMID38206030
PMCPMC10845965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.