Evidence map›Paper›PMID 38205934›Full record

ArticleMagnetic resonance in medicine2024

First in-human evaluation of [1-

Kofi Deh, Guannan Zhang, Angela Hijin Park, Charles H Cunningham, Nadia D Bragagnolo, Serge Lyashchenko, Shake Ahmmed, Avigdor Leftin, Elizabeth Coffee, Hedvig Hricak and 3 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Multi-Vendor and Multi-Site Characterization ofMagnetic resonance in medicine · 2026
    Article
  2. Hyperpolarization of PyridineAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Over four minutes of pyruvate TNature communications · 2026
    Article
  4. [3-Npj imaging · 2026
    Article
  5. Increasing Infusion Times of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  6. Review
  7. Review
  8. Imaging in Neuro-oncology.Seminars in neurology · 2025
    Review
  9. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  10. Article
  11. Assessment of the Feasibility of Hyperpolarized [1-Journal of magnetic resonance imaging : JMRI · 2024
    Article
  12. Enhanced Solubility and Polarization ofACS applied materials & interfaces · 2024
    Article
  13. Article
  14. Hyperpolarized [2-ACS sensors · 2024
    Article
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Kofi DehDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-3919-2543
Guannan ZhangDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Angela Hijin ParkRadiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Charles H CunninghamPhysical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0001-9636-8130
Nadia D BragagnoloPhysical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0002-3399-2267
Serge LyashchenkoRadiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Shake AhmmedRadiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Avigdor LeftinGeneral Electric Healthcare, New York, New York, USA.
Elizabeth CoffeeDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hedvig HricakDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Vesselin MiloushevDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Marius MayerhoeferDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Kayvan R KeshariDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-5181-8035
Memorial Sloan Kettering Cancer Center · USSunnybrook Health Science Centre · CAGeneral Electric (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Leveraging fructose transport to create a privileged substrate to selectively fuel T cellsR01CA248364 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Kayvan R Keshari · 2021 to 2026
$4.3M
Development of large-field-of-view hyperpolarized MRIR01CA237466 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CUNNINGHAM, CHARLES H., HRICAK, HEDVIG · 2020 to 2024
$3.4M
Visualizing oxidative stress using hyperpolarized magnetic resonanceR01CA252037 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KESHARI, KAYVAN R · 2020 to 2024
$3.3M
Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapyR01CA249294 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KESHARI, KAYVAN R, MERGHOUB, TAHA · 2021 to 2025
$2.6M
GE Diamond DNP PolarizerS10OD016422 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI HRICAK, HEDVIG, KESHARI, KAYVAN R · 2014 to 2014
$600k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA237466NCI NIH HHS R01 CA248364NCI NIH HHS R01 CA249294NCI NIH HHS R01 CA252037NIBIB NIH HHS P41 EB013598NIH HHS R01CA237466NIH HHS R01CA248364NIH HHS R01CA249294NIH HHS R01CA252037NIH HHS S10 OD016422NIH HHS S10OD016422
6 · The paper itself

Abstract

purposeTo investigate the safety and value of hyperpolarized (HP) MRI of [1-

methodsHealthy volunteers (n = 5), were injected with HP [1-

resultsAll volunteers completed the study safely and reported no adverse effects. The use of D

conclusionsHP [1-

Indexed as

Magnetic Resonance ImagingPyruvic AcidBrainCarbon IsotopesFeasibility StudiesHumansSolventsCarbon IsotopesPyruvic AcidSolventsbraindeuterium oxide (D2O)hyperpolarized 13C‐pyruvate

Identifiers

PMID38205934
PMCPMC11009889
OpenAlexW4390740514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.