Evidence map›Paper›PMID 38205829›Full record

ArticleHistology and histopathology2024

Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall.

Linwei Zuo, Huiyan You, Zhe Cai, Shousheng Liao, Xiangtong Lu, Lixiang Li, Wenyong Huang

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Article in Histology and histopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Linwei ZuoDepartment of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Huiyan YouDepartment of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Zhe CaiDepartment of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Shousheng LiaoDepartment of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Xiangtong LuDepartment of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Lixiang Li *Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Wenyong Huang *Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. Wenyongh2009@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMelan-A/MART-1 is a melanocytic differentiation marker recognized as an antigen on melanoma cells. It is a useful diagnostic marker for pathologists in the diagnosis of melanocytic tumors. However, we recently found that Melan-A can be expressed in some non-melanocytic carcinomas that are rarely reported in the literature.

methodsWe analyzed the expression of Melan-A in 87 non-melanocytic carcinoma tissue samples by immunohistochemistry. Marker positivity was defined as ≥10% positive tumor cells.

resultsIn 87 non-melanocytic carcinoma tissue samples, Melan-A was positive in six (6.89%) cases, of which four (66.7%) were male and two (33.3%) were female, with a mean age of 60 years (range 21-82 years). Five (83.3%) of the Melan-A-positive cases had distant metastases. Compared with Melan-A negative cases, Melan-A positive non-melanocytic carcinomas were significantly associated with poor prognosis (

conclusionsMelan-A expression is relatively rare in non-melanocytic carcinoma cases. This report highlights a potential diagnostic pitfall in the diagnosis of melanoma, urges pathologists to exercise caution in cases of Melan-A positivity, and illustrates the need for an immunohistochemical marker panel to avoid misdiagnosis.

Indexed as

Biomarkers, TumorImmunohistochemistryMART-1 AntigenAdultAgedAged, 80 and overCarcinomaDiagnosis, DifferentialFemaleHumansMaleMelanomaMiddle AgedPrognosisSkin NeoplasmsYoung AdultBiomarkers, TumorMART-1 AntigenMLANA protein, human

Identifiers

PMID38205829

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