Evidence map›Paper›PMID 38205679›Full record

ArticleCell transplantation

Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm.

Cheng-Fong Chen, Yi-Chung Chen, Yu-Show Fu, Shang-Wen Tsai, Po-Kuei Wu, Chao-Ming Chen, Wei-Ming Chen, Hung-Ta Hondar Wu, Chia-Hsin Lee, Chao-Liang Chang and 4 more

Open access · goldAbstract readClinical Trial, Phase IControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Cheng-Fong ChenDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.ORCID 0000-0002-2485-6159
Yi-Chung ChenDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Yu-Show FuDepartment of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Shang-Wen TsaiDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Po-Kuei WuDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Chao-Ming ChenDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Wei-Ming ChenDepartment of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Hung-Ta Hondar WuDepartment of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Chia-Hsin LeeGwo Xi Stem Cell Applied Technology Co., Ltd., Hsinchu, Taiwan, ROC.
Chao-Liang ChangGwo Xi Stem Cell Applied Technology Co., Ltd., Hsinchu, Taiwan, ROC.
Po-Cheng LinGwo Xi Stem Cell Applied Technology Co., Ltd., Hsinchu, Taiwan, ROC.
Yong-Cheng KaoGwo Xi Stem Cell Applied Technology Co., Ltd., Hsinchu, Taiwan, ROC.
Chun-Hung ChenGwo Xi Stem Cell Applied Technology Co., Ltd., Hsinchu, Taiwan, ROC.
Ming-Hsi ChuangInstitute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
National Yang Ming Chiao Tung University · TWStem Cell Technology (Taiwan) · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 phase I study was designed with two dose-escalation cohorts: low dose (6.7 × 10

Indexed as

Mesenchymal Stem CellsOsteoarthritis, KneeHumansInjections, Intra-ArticularPainPilot Projectsallogeneic adipose-derived mesenchymal stem cells (ADSCs)GXCPC1knee osteoarthritissafetytolerability

Identifiers

PMID38205679
PMCPMC10785714
OpenAlexW4390740624

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.