Evidence map›Paper›PMID 38205637›Full record

ArticleFuture medicinal chemistry2024

Synthesis and evaluation of 2,5-substituted pyrimidines as small-molecule gankyrin binders.

Dipti Kanabar, Emma I Kane, Tejashri Chavan, Taylor M Laflamme, Ethan Suarez, Mimansa Goyal, Vivek Gupta, Donald E Spratt, Aaron Muth

Open access · greenAbstract read
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dipti KanabarDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11439, USA.ORCID 0000-0001-6541-6494
Emma I KaneGustaf H. Carlson School of Chemistry & Biochemistry, Clark University, Worcester, MA 01610, USA.ORCID 0000-0002-5054-3850
Tejashri ChavanDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11439, USA.ORCID 0009-0001-2886-6506
Taylor M LaflammeGustaf H. Carlson School of Chemistry & Biochemistry, Clark University, Worcester, MA 01610, USA.
Ethan SuarezDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11439, USA.
Mimansa GoyalDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11439, USA.
Vivek GuptaDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11439, USA.ORCID 0000-0002-3618-8178
Donald E SprattGustaf H. Carlson School of Chemistry & Biochemistry, Clark University, Worcester, MA 01610, USA.ORCID 0000-0002-0699-155X
Aaron MuthDepartment of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, St. John's University, Queens, NY 11439, USA.ORCID 0000-0002-0646-9964
St. John's University · USClark University · US

Funding

Structure and Mechanism of HERC5-dependent ISGylationR15GM126432 · NIGMS · CLARK UNIVERSITY (WORCESTER, MA) · PI SPRATT, DONALD ERIC · 2017 to 2023
$1000k
Developing Chemical Probes to Decipher Gankyrin BiologySC2GM139672 · NIGMS · ST. JOHN'S UNIVERSITY · PI MUTH, AARON · 2021 to 2023
$492k
NIGMS NIH HHS R15 GM126432NIGMS NIH HHS R15GM126432, SC2GM139672NIGMS NIH HHS SC2 GM139672
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

NeoplasmsTumor Suppressor Protein p53Cell Line, TumorHumansProteasome Endopeptidase ComplexProteasome Endopeptidase ComplexTumor Suppressor Protein p53breast cancergankyrinlung cancerprotein–protein interactionstumor suppressor proteins

Identifiers

PMID38205637
PMCPMC10853842
OpenAlexW4390743096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.