Evidence map›Paper›PMID 38205514›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2024

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.

Elisa Rojas-Prats, Loreto Martinez-Gonzalez, Carmen Gil, David Ramírez, Ana Martinez

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Elisa Rojas-PratsCentro de Investigaciones Biológicas -Margarita Salas-CSIC, Madrid, Spain.ORCID 0000-0002-5747-8764
Loreto Martinez-GonzalezCentro de Investigaciones Biológicas -Margarita Salas-CSIC, Madrid, Spain.ORCID 0000-0003-4593-4889
Carmen GilCentro de Investigaciones Biológicas -Margarita Salas-CSIC, Madrid, Spain.ORCID 0000-0002-3882-6081
David RamírezDepartamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.ORCID 0000-0003-0002-1189
Ana MartinezCentro de Investigaciones Biológicas -Margarita Salas-CSIC, Madrid, Spain.ORCID 0000-0002-2707-8110
Biomedical Research Networking Center on Neurodegenerative Diseases · ESCentro de Investigaciones Biológicas Margarita Salas · ESUniversity of Concepción · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation

Indexed as

Nuclear ProteinsProtein Serine-Threonine KinasesAllosteric SiteCell CycleCell Cycle ProteinsCell LineHumansPhosphorylationCDC7 protein, humanCell Cycle ProteinsNuclear ProteinsProtein Serine-Threonine Kinasesallosteric modulatorbinding pocketsCDC7DBF4virtual screening

Identifiers

PMID38205514
PMCPMC10786434
OpenAlexW4390741772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.