Evidence map›Paper›PMID 38205351›Full record

ArticleJACC. Basic to translational science2023

Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade.

Qixin Yang, Hanna J Tadros, Bo Sun, Minu-Tshyeto Bidzimou, Jordan E Ezekian, Feng Li, Andreas Ludwig, Xander H T Wehrens, Andrew P Landstrom

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Nonstructural Roles of Junctophilin-2 in the Heart.JACC. Basic to translational science · 2025
    Review
  3. Circulation research · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Qixin YangDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Hanna J TadrosSection of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Bo SunDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Minu-Tshyeto BidzimouDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Jordan E EzekianDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Feng LiCenter for Drug Discovery and Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Andreas LudwigInstitut für Experimentelle und Klinische Pharmakologie, und Toxikologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Xander H T WehrensSection of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Andrew P LandstromDivision of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · USBaylor College of Medicine · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
NHLBI NIH HHS R01 HL153350NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

Junctional ectopic tachycardia (JET) is a potentially fatal cardiac arrhythmia. Hcn4:shJph2 mice serve as a model of nodal arrhythmias driven by ryanodine type 2 receptor (RyR2)-mediated Ca

Indexed as

calciumJETJph2junctional ectopic tachycardiaryanodine receptor

Identifiers

PMID38205351
PMCPMC10774596
OpenAlexW4387091663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.