Determination of trace elements in ibuprofen drug products using microwave-assisted acid digestion and inductively coupled plasma-mass spectrometry.

Else Holmfred, Abdulla Alrijjal, C Page Chamberlain, Katharine Maher, Stefan Stürup

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Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.9field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Else HolmfredDepartment of Earth and Planetary Sciences, Stanford University, Stanford, CA, USA.

Abdulla AlrijjalDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

C Page ChamberlainDepartment of Earth and Planetary Sciences, Stanford University, Stanford, CA, USA.

Katharine MaherDepartment of Earth System Sciences, Stanford University, Stanford, CA, USA.

Stefan StürupDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Planetary Science Institute · USUniversity of Copenhagen · DKStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trace elements are found in most drugs as a result of the drug formulation and drug production methods. An inductively coupled plasma-mass spectrometry method for the determination of 24 trace elements (Mg, Ti, V, Cr, Mn, Cu, Fe, Co, Ni, Zn, As, Se, Mo, Ru, Rh, Pd, Ag, Cd, Sb, Ba, Ir, Pt, Au, and Pb) in solid ibuprofen tablets was established in relation to the ICH Q3D(R1) guideline, to evaluate the possibility of linking trace elemental profiles to drug formulation strategies, and to differentiate between drug products based on the trace elemental profiles. Ten European ibuprofen drug products were evaluated (n=3). The sample preparation was performed by microwave-assisted acid digestion using only 10 mg of homogenized sample and 900 μL of a mix of 65% HNO

Indexed as

Acid digestionAnalytical chemistryIbuprofenICP-MSPharmaceuticalsTrace elemental impurities

Identifiers

PMID38205305

DOI10.1016/j.heliyon.2023.e23566

PMCPMC10776936

OpenAlexW4389522922

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.