ArticleACS catalysis2024
Application of the C3-Methyltransferase StspM1 for the Synthesis of the Natural Pyrroloindole Motif.
Article in ACS catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Structure-Guided Engineering of a Promiscuous O-Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Characterisation of the N-Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines.Angewandte Chemie (International ed. in English) · 2026Article
- Re-engineering a transferase scaffold for indole C3 methylation in diketopiperazines.Protein science : a publication of the Protein Society · 2025Article
- Chemoenzymatic Total Synthesis of Lansai B.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Advanced exploitation of unmerged reflection data during processing and refinement with autoPROC and BUSTER.Acta crystallographica. Section D, Structural biology · 2024Article
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Authors and funding
8 authors.
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Abstract
Even though pyrroloindoles are widely present in natural products with different kinds of biological activities, their selective synthesis remains challenging with existing tools in organic chemistry, and there is furthermore a demand for stereoselective and mild methods to access this structural motif. Nature uses C3-methyltransferases to form the pyrroloindole framework, starting from the amino acid tryptophan. In the present study, the SAM-dependent methyltransferase StspM1 from
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