Evidence map›Paper›PMID 38204927›Full record

ArticleIJID regions2024

Comparative reconstruction of SARS-CoV-2 transmission in three African countries using a mathematical model integrating immunity data.

Bechir Naffeti, Walid BenAribi, Amira Kebir, Maryam Diarra, Matthieu Schoenhals, Inès Vigan-Womas, Koussay Dellagi, Slimane BenMiled

Open access · goldAbstract read
In one paragraph

Article in IJID regions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Bechir NaffetiUniversity of Tunis el Manar, Institut Pasteur de Tunis, Bio-(Informatic, Mathematics and Statistic) BIMS-Lab LR09-IPT16, Tunis, Tunisia.
Walid BenAribiUniversity of Tunis el Manar, Institut Pasteur de Tunis, Bio-(Informatic, Mathematics and Statistic) BIMS-Lab LR09-IPT16, Tunis, Tunisia.
Amira KebirUniversity of Tunis el Manar, Institut Pasteur de Tunis, Bio-(Informatic, Mathematics and Statistic) BIMS-Lab LR09-IPT16, Tunis, Tunisia.
Maryam DiarraInstitut Pasteur de Dakar, Epidemiology, Clinical Research and Data Sciences Department, Dakar, Senegal.
Matthieu SchoenhalsInstitut Pasteur de Madagascar, Immunology of Infectious Diseases Unit, Antananarivo, Madagascar.
Inès Vigan-WomasInstitut Pasteur de Dakar, Immuno-physiopathology and Infectious Diseases Department, Dakar, Senegal.
Koussay DellagiPasteur Network, Institut Pasteur, Paris, France.
Slimane BenMiledUniversity of Tunis el Manar, Institut Pasteur de Tunis, Bio-(Informatic, Mathematics and Statistic) BIMS-Lab LR09-IPT16, Tunis, Tunisia.
Institut Pasteur de Tunis · TNInstitut Pasteur de Dakar · SNInstitut Pasteur · FRInstitut Pasteur de Madagascar · MGTunis University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Africa has experienced fewer COVID-19 cases and deaths than other regions, with a contrasting epidemiological situation between countries, raising questions regarding the determinants of disease spread in Africa. Methods: We built a susceptible-exposed-infected-recovered model including COVID-19 mortality data where recovery class is structured by specific immunization and modeled by a partial differential equation considering the opposed effects of immunity decline and immunization. This model was applied to Tunisia, Senegal, and Madagascar. Results: Senegal and Tunisia experienced two epidemic phases. Initially, infections emerged in naive individuals and were limited by social distancing. Variants of concern (VOCs) were also introduced. The second phase was characterized by successive epidemic waves driven by new VOCs that escaped host immunity. Meanwhile, Madagascar demonstrated a different profile, characterized by longer intervals between epidemic waves, increasing the pool of susceptible individuals who had lost their protective immunity. The impact of vaccination on model parameters in Tunisia and Senegal was evaluated. Conclusions: Loss of immunity and vaccination-induced immunity have played crucial role in controlling the African pandemic. SARS-CoV-2 has become endemic now and will continue to circulate in African populations. However, previous infections provide significant protection against severe diseases, thus providing a basis for future vaccination strategies.

Indexed as

AfricaCovid-19EpidemiologyImmunitymodellingPublic health measuresSARS-CoV-2SEIR/DS modelVaccine-induced immunity

Identifiers

PMID38204927
PMCPMC10776948
OpenAlexW4388948456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.