Evidence map›Paper›PMID 38204795›Full record

ArticleRoyal Society open science2024

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical

Raelene M Cowie, Laura Macri-Pellizzeri, Jane McLaren, William J Sanderson, Reda M Felfel, Colin A Scotchford, Brigitte E Scammell, David M Grant, Virginie Sottile, Louise M Jennings

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raelene M CowieInstitute of Medical and Biological Engineering, University of Leeds, Leeds, UK.ORCID 0000-0003-3903-5916
Laura Macri-PellizzeriAcademic Unit Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Jane McLarenAcademic Unit Injury, Recovery and Inflammation Sciences (IRIS), School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0001-5662-1429
William J SandersonInstitute of Medical and Biological Engineering, University of Leeds, Leeds, UK.
Reda M FelfelAdvanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham, UK.
Colin A ScotchfordAdvanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham, UK.ORCID 0000-0003-1937-6692
Brigitte E ScammellAcademic Unit Injury, Recovery and Inflammation Sciences (IRIS), School of Medicine, University of Nottingham, Nottingham, UK.
David M GrantAdvanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham, UK.ORCID 0000-0002-6786-7720
Virginie SottileAcademic Unit Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
Louise M JenningsInstitute of Medical and Biological Engineering, University of Leeds, Leeds, UK.ORCID 0000-0003-1446-4511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different graft sources/materials which replicate natural cartilage function. Chitosan has been proposed for this application. The aim of this study was to assess the biomechanics and biotribology of a bioresorbable chitosan/chitosan-nano-hydroxyapatite osteochondral construct (OCC), implanted in an

Indexed as

chitosanjoint simulationnatural knee jointosteochondral grafttribology

Identifiers

PMID38204795
PMCPMC10776221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.