Evidence map›Paper›PMID 38204264›Full record

ArticleCurrent radiopharmaceuticals2024

The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure.

Gang Yin, Qinqi Wang, Tongtong Lv, Yifan Liu, Xiaochun Peng, Xianqin Zeng, Jiangrong Huang

Abstract read
In one paragraph

Article in Current radiopharmaceuticals, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gang YinDepartment of Neurology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Qinqi WangDepartment of Internal Medicine, Wuhan No.1 Hospital, Wuhan, Hubei, China.
Tongtong LvDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.
Yifan LiuDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.
Xiaochun PengDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.ORCID 0000-0001-9443-0439
Xianqin ZengDepartment of Gynaecology and Obstetrics, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jiangrong HuangDepartment of Integrative Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei, China.

Funding

Hubei Provincial Population and Family Planning Commission WJ2019-02National Natural Science Foundation of China (NSFC) 31800980Traditional Chinese Medicine Bureau of Guangdong Province ZY2019Q036,GZY-FJS-2021-222,GZY-FJS-2020-221
6 · The paper itself

Abstract

backgroundRadiation exposure has been linked to the development of brain damage and cognitive impairment, but the protective effect and mechanism of Lycium barbarum pills (LBP) on radiation-induced neurological damage remains to be clarified.

methodsBehavioral tests and immunohistochemical studies were conducted to evaluate the protective effects of LBP extract (10 g/kg orally daily for 4 weeks) against radiation-induced damage on neurogenesis and cognitive function in Balb/c mice exposed to 5.5 Gy X-ray acute radiation.

resultsThe results showed that the LBP extract significantly improved body weight loss, locomotor activity and spatial learning and memory. Immunohistochemical tests revealed that the LBP extract prevented the loss of proliferating cells, newly generated neurons and interneurons, especially in the subgranular area of the dentate gyrus.

conclusionThe findings suggest that LBP is a potential neuroprotective drug for mitigating radiation-induced neuropsychological disorders.

Indexed as

CognitionMice, Inbred BALB CNeurogenesisRadiation-Protective AgentsAnimalsDrugs, Chinese HerbalLyciumMaleMiceNeuroprotective AgentsRadiation ExposureRadiation Injuries, ExperimentalDrugs, Chinese HerbalNeuroprotective AgentsRadiation-Protective Agentsbrain damagecognitive impairment.LBPneurogenesisoxidative stressradiation exposureradioprotective

Identifiers

PMID38204264
PMCPMC11327742

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.