Evidence map›Paper›PMID 38204229›Full record

ArticleCurrent medicinal chemistry2024

Perillyl Alcohol Promotes Relaxation in Human Umbilical Artery.

Carla Mikevely de Sena Bastos, Luis Pereira-de-Morais, Andressa de Alencar Silva, Débora de Menezes Dantas, Paulo Ricardo Batista, Maria Franciele Lima Gomes, Gyllyandeson de Araújo Delmondes, Irwin Rose Alencar de Menezes, Renata Evaristo Rodrigues da Silva, Roseli Barbosa

Abstract read
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Article in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carla Mikevely de Sena BastosBiological Chemistry Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Luis Pereira-de-MoraisPhysiopharmacology of Excitable Cells Laboratory, Biological Sciences Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Andressa de Alencar SilvaPhysiopharmacology of Excitable Cells Laboratory, Biological Sciences Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Débora de Menezes DantasBiological Chemistry Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Paulo Ricardo BatistaBiological Chemistry Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Maria Franciele Lima GomesPhysiopharmacology of Excitable Cells Laboratory, Biological Sciences Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Gyllyandeson de Araújo DelmondesNursing Collegiate, Petrolina Campus, Federal University of The San Francisco Vale, Petrolina 56304-205, Pernambuco, Brazil.
Irwin Rose Alencar de MenezesBiological Chemistry Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Renata Evaristo Rodrigues da SilvaBiological Chemistry Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.
Roseli BarbosaBiological Chemistry Department, Pimenta Campus, Regional University of Cariri, Crato 63105-000, Ceará, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerillyl alcohol (POH) is a monoterpenoid found in plant essential oils and has been shown to relax murine vessels, but its effect on human vessels remains poorly studied.

objectiveThe study aimed to characterize the effect of POH on human umbilical arteries (HUA).

methodsRings of HUA were obtained from uncomplicated patients and suspended in an organ bath for isometric recording. The vasorelaxant effect of POH in HUA was evaluated on basal tone and electromechanical or pharmacomechanical contractions, and possible mechanisms of action were also investigated.

resultsPOH (1-1000 μM) altered the basal tone of HUA and completely relaxed HUA rings precontracted with KCl (60 mM) or 5-HT (10 μM), obtaining greater potency in the pharmacomechanical pathway (EC

conclusionThe data from this study suggest that POH modulates Ca

Indexed as

MonoterpenesUmbilical ArteriesDose-Response Relationship, DrugHumansVasodilationVasodilator AgentsMonoterpenesperillyl alcoholVasodilator Agentshuman umbilical arterymurine vesselsPerillyl alcoholpotassium channel blockers.serotoninergic pathwayvasorelaxation

Identifiers

PMID38204229

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.