Evidence map›Paper›PMID 38204228›Full record

ArticleCurrent medicinal chemistry2025

Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.

Wei Liu, Yi-Nan Zheng, Shuang Jiang, Shen Ren, Shan Tang, Jing Zhang, Zi Wang, Wei Li

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Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei LiuCollege of Pharmacy, Beihua University, jilin 132013, China.
Yi-Nan ZhengCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Shuang JiangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Shen RenCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Shan TangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Jing ZhangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Zi WangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Wei LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID 0000-0002-2988-4298

Funding

Changchun Science & Technology Development Plan 21ZGY11Jilin Science & Technology Development Plan 20200301037RQNational Natural Science Foundation of China 82104465Scientific Research Planning Project of Jilin Provincial Department of Education JJKH20220371KJ
6 · The paper itself

Abstract

backgroundBased on the Maillard reaction principle of red ginseng, this study innovatively synthesized a new amino acid derivative by combining arginine with lactose through simulated synthesis and was separated and purified through repeated silica gel and polyacrylamide gel (Bio-gel P-II) column chromatography. PURPOSE: The work was aimed at elucidating the synthesis of a novel amino acid derivative and investigating the intestinal protective activity of the novel amino acid derivative and possible molecular mechanism by establishing the intestinal injury model induced by cisplatin in mice.

methodsThe purity and molecular weight of the amino acid derivatives were determined to be by electrospray ionization mass spectrometry (ESI-MS). Subsequently, by establishing cisplatin (20 mg/kg)-induced intestinal injury

resultsThe new amino acid derivatives of chemical structure were identified to be 1- (arginine-N

conclusionThe results clearly revealed AFGA as a potential multifunctional therapeutic agent with a clear protective effect against cisplatin-induced intestinal injury may be related to the PI3K/Akt signaling pathway.

Indexed as

Amino AcidsApoptosisArginineCisplatinGalactoseIntestinesReactive Oxygen SpeciesAnimalsAntineoplastic AgentsCell LineMaleMiceOxidative StressRatsSignal TransductionAmino AcidsAntineoplastic AgentsArginineCisplatinGalactoseReactive Oxygen Speciesanti-apoptosis.Argininyl-fructosyl-galactosecisplatinintestinal toxicityreactive oxygen speciesstructure identification

Identifiers

PMID38204228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.