Evidence map›Paper›PMID 38203840›Full record

ArticleInternational journal of molecular sciences2024

Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR-STAT3 Signaling Pathway in Canine Mammary Tumors.

Chen Mei, Xue Zhang, Yan Zhi, Zhixuan Liang, Haojun Xu, Zhenyi Liu, Ying Liu, Yanli Lyu, Hongjun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chen MeiInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Xue ZhangInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Yan ZhiInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Zhixuan LiangInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Haojun XuInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Zhenyi LiuInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Ying LiuInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Yanli LyuDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China.
Hongjun WangInstitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 11 Shuguanghuayuan Middle Road, Haidian District, Beijing 100097, China.
Beijing Academy of Agricultural and Forestry Sciences · CNChina Agricultural University · CN

Funding

the Project of the Beijing Academy of Agriculture and Forestry Science the Project of the Beijing Academy of Agriculture and Forestry Sciencethe Reform and Development Project of Beijing Academy of Agricultural and Forestry Sciences Grant No. XMS202319
6 · The paper itself

Abstract

Programmed death ligand-1 (PD-L1) is highly expressed in a variety of cancer cells and suggests a poorer prognosis for patients. The natural compound isorhamnetin (ISO) shows promise in treating cancers and causing damage to canine mammary tumor (CMT) cells. We investigated the mechanism of ISO in reducing PD-L1 expression in CMT cells. Clustered, regularly interspaced short palindromic repeat-associated protein 9 (CRISPR/Cas9) was used to mediate

Indexed as

B7-H1 AntigenBreast NeoplasmsQuercetinAnimalsDogsErbB ReceptorsLigandsMiceSignal TransductionSTAT3 Transcription Factor3-methylquercetinB7-H1 AntigenErbB ReceptorsLigandsQuercetinSTAT3 Transcription Factorcanine mammary tumorEGFR-STAT3 signaling pathwayisorhamnetinprogrammed death ligand-1 (PD-L1)surface plasmon resonance (SPR)target protein

Identifiers

PMID38203840
PMCPMC10779303
OpenAlexW4390580856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.