Evidence map›Paper›PMID 38203816›Full record

ArticleInternational journal of molecular sciences2024

ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia.

Justine Lai, Claire Yang, Chuquan Shang, Will Chen, Michael P Chu, Joseph Brandwein, Raymond Lai, Peng Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. T-lymphocytes suppression by CD14Journal of translational medicine · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Justine LaiDepartment of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0001-8901-561X
Claire YangDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Chuquan ShangDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0003-4240-2166
Will ChenDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Michael P ChuDepartment of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Joseph BrandweinDepartment of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Raymond LaiDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0002-6963-2407
Peng WangDepartment of Medicine, Division of Hematology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0009-0005-4000-6372
University of Alberta · CA

Funding

Marshall Eliuk Fund N/ARachel Mandel Lymphoma and Blood Cancers Research Fund N/A
6 · The paper itself

Abstract

We recently demonstrated that a small subset of cells in FLT3-mutated acute myeloid leukemia (AML) cell lines exhibit SORE6 reporter activity and cancer stem-like features including chemoresistance. To study why SORE6

Indexed as

Drug Resistance, NeoplasmLeukemia, Myeloid, AcuteProtein Serine-Threonine KinasesAutophagyBiological AssayChronic DiseaseCytarabinefms-Like Tyrosine Kinase 3HumansCytarabineFLT3 protein, humanfms-Like Tyrosine Kinase 3Protein Serine-Threonine KinasesUlk2 protein, humanacute myeloid leukemiaautophagycancer stemnessrelapse

Identifiers

PMID38203816
PMCPMC10780038
OpenAlexW4390586512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.