Evidence map›Paper›PMID 38203701›Full record

ArticleInternational journal of molecular sciences2023

Analysis of the Methylation Level of the

Remigiusz Recław, Milena Lachowicz, Krzysztof Chmielowiec, Jolanta Chmielowiec, Aleksandra Strońska-Pluta, Michał Tomasz Kowalski, Bartosz Kudliński, Anna Grzywacz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Remigiusz RecławFoundation Strong in the Spirit, 60 Sienkiewicza St., 90-058 Łodz, Poland.ORCID 0009-0004-7841-821X
Milena LachowiczDepartment of Psychology, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1 St., 80-336 Gdansk, Poland.ORCID 0000-0002-8402-0564
Krzysztof ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Gora, Poland.ORCID 0000-0003-4254-5466
Jolanta ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Gora, Poland.ORCID 0000-0003-3285-5313
Aleksandra Strońska-PlutaIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0001-6564-2141
Michał Tomasz KowalskiClinical Department of Cardiology, Nowa Sól Multidisciplinary Hospital, 67-100 Nowa Sol, Poland.
Bartosz KudlińskiDepartment of Emergency Medicine, Anesthesiology and Intensive Care in K. Marcinkowski University Hospital, Collegium Medicum, University of Zielona Góra, 65-046 Zielona Gora, Poland.ORCID 0000-0002-7687-1887
Anna GrzywaczIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.
University of Zielona Góra · PLPomeranian Medical University · PLFoundation of Cardiac Surgery Development · PLGdansk University of Physical Education and Sport · PL

Funding

This project was financed by the program of the Minister of Science and Higher Education in Poland under the name "Regional Initiative of Excellence" in 2019-2022, project number 002/RID/2018/19, amount of financing 12,000,000 PLN 002/RID/2018/19
6 · The paper itself

Abstract

Drug addiction is a chronic biochemical drug use disorder that affects the human brain and behavior and leads to the uncontrolled use of legal or illicit drugs. It has been shown that three factors are involved in the development of addiction: genetic factors, a diverse environment, and the effect of medication on gene expression. The comprehensive approach and holistic analysis of the problem are due to the multigenic and multifactorial nature of addiction. Dopamine, one of the major neurotransmitters in the brain, is believed to be the "culprit" that leads to a drug abuse-induced "high". That is why, in our research, we focused mainly on the genes related to dopaminergic reuptake. In the present study, we chose methylation of the

Indexed as

Central Nervous System StimulantsIllicit DrugsDNA MethylationDopamineDopamine Plasma Membrane Transport ProteinsHumansPersonalityCentral Nervous System StimulantsDopamineDopamine Plasma Membrane Transport ProteinsIllicit DrugsDAT1dopamine transportermethylationNEO-FFIstimulant dependence

Identifiers

PMID38203701
PMCPMC10779366
OpenAlexW4390471270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.