Evidence map›Paper›PMID 38203602›Full record

ArticleInternational journal of molecular sciences2023

Matthew P O'Brien, Marina V Pryzhkova, Evelyn M R Lake, Francesca Mandino, Xilin Shen, Ruchika Karnik, Alisa Atkins, Michelle J Xu, Weizhen Ji, Monica Konstantino and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Matthew P O'BrienDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.ORCID 0009-0008-5190-1868
Marina V PryzhkovaBiochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Evelyn M R LakeDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.ORCID 0000-0001-8255-8013
Francesca MandinoDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Xilin ShenDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Ruchika KarnikDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Alisa AtkinsBiochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Michelle J XuBiochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.
Weizhen JiDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Monica KonstantinoDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Martina BruecknerDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Laura R MentDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Mustafa K KhokhaDepartment of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Philip W JordanBiochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA.ORCID 0000-0003-4890-2647
Yale University · USJohns Hopkins University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$11.5M
Regulation of microtubule organizing centers during mammalian gametogenesisR01GM117155 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Philip W Jordan · 2016 to 2026
$4.3M
A system approach to the analysis of Heterotaxy Candidate GenesR01HD102186 · NICHD · YALE UNIVERSITY · PI KHOKHA, MUSTAFA K · 2020 to 2024
$3.1M
Pluripotent stem cell-derived organoid model of human gonad development, functions, and disordersR01HD114180 · NICHD · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI JORDAN, PHILIP W · 2023 to 2025
$1.7M
Determining the requirements for the SMC5/6 complex during neurodevelopment and post-mitotic neuron functionR03NS106486 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JORDAN, PHILIP W · 2019 to 2020
$164k
NCATS NIH HHS UL1 TR001863NCI NIH HHS T32 CA009110NICHD NIH HHS R01 HD102186NICHD NIH HHS R01 HD114180NIGMS NIH HHS R01 GM117155NIGMS NIH HHS R01GM11755NIMH NIH HHS P50 MH115716NIMH NIH HHS P50MH115716NINDS NIH HHS R03 NS106486NINDS NIH HHS R03NS106486
6 · The paper itself

Abstract

Up to 50% of patients with severe congenital heart disease (CHD) develop life-altering neurodevelopmental disability (NDD). It has been presumed that NDD arises in CHD cases because of hypoxia before, during, or after cardiac surgery. Recent studies detected an enrichment in de novo mutations in CHD and NDD, as well as significant overlap between CHD and NDD candidate genes. However, there is limited evidence demonstrating that genes causing CHD can produce NDD independent of hypoxia. A patient with hypoplastic left heart syndrome and gross motor delay presented with a de novo mutation in

Indexed as

Heart Defects, CongenitalAnimalsBrainCell Cycle ProteinsChromosomal Proteins, Non-HistoneHeart VentriclesHumansHypoxiaMiceMyocytes, CardiacXenopusXenopus ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneSMC5 protein, humanSMC5 protein, mouseSmc5 protein, XenopusXenopus Proteinscardiomyocytescongenital heart diseasefunctional connectivityfunctional MRIhypoplastic left heart syndromeneurodevelopmentstructural maintenance of chromosomes

Identifiers

PMID38203602
PMCPMC10779392
OpenAlexW4390347113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.