Evidence map›Paper›PMID 38203577›Full record

ReviewInternational journal of molecular sciences2023

Long COVID: Molecular Mechanisms and Detection Techniques.

Adela Constantinescu-Bercu, Andrei Lobiuc, Olga Adriana Căliman-Sturdza, Radu Cristian Oiţă, Monica Iavorschi, Naomi-Eunicia Pavăl, Iuliana Șoldănescu, Mihai Dimian, Mihai Covasa

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Molecular Interplay Between COVID-19 and Stroke: Experimental Insights Into MicroRNA-Regulated Neuroinflammation.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Long COVID-19: A Concept Analysis.Infectious disease reports · 2025
    Article
  11. Review
  12. Review
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Adela Constantinescu-BercuDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University of Suceava, 720229 Suceava, Romania.
Andrei LobiucDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University of Suceava, 720229 Suceava, Romania.
Olga Adriana Căliman-SturdzaDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University of Suceava, 720229 Suceava, Romania.ORCID 0000-0003-2274-6439
Radu Cristian OiţăIntegrated Center for Research, Development and Innovation for Advanced Materials, Nanotechnologies, Manufacturing and Control Distributed Systems (MANSiD), Ştefan cel Mare University of Suceava, 720229 Suceava, Romania.
Monica IavorschiDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University of Suceava, 720229 Suceava, Romania.
Naomi-Eunicia PavălDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University of Suceava, 720229 Suceava, Romania.
Iuliana ȘoldănescuIntegrated Center for Research, Development and Innovation for Advanced Materials, Nanotechnologies, Manufacturing and Control Distributed Systems (MANSiD), Ştefan cel Mare University of Suceava, 720229 Suceava, Romania.
Mihai DimianIntegrated Center for Research, Development and Innovation for Advanced Materials, Nanotechnologies, Manufacturing and Control Distributed Systems (MANSiD), Ştefan cel Mare University of Suceava, 720229 Suceava, Romania.ORCID 0000-0002-2093-8659
Mihai CovasaDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Ştefan cel Mare" University of Suceava, 720229 Suceava, Romania.
Ştefan cel Mare University of Suceava · RO

Funding

Ministry of Research, Innovation and Digitization, CNCS - UEFISCDI PN-III-Pl-1.1-PD-2021-0273, within PNCDI III
6 · The paper itself

Abstract

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a significant health concern following the COVID-19 pandemic. Molecular mechanisms underlying the occurrence and progression of long COVID include viral persistence, immune dysregulation, endothelial dysfunction, and neurological involvement, and highlight the need for further research to develop targeted therapies for this condition. While a clearer picture of the clinical symptomatology is shaping, many molecular mechanisms are yet to be unraveled, given their complexity and high level of interaction with other metabolic pathways. This review summarizes some of the most important symptoms and associated molecular mechanisms that occur in long COVID, as well as the most relevant molecular techniques that can be used in understanding the viral pathogen, its affinity towards the host, and the possible outcomes of host-pathogen interaction.

Indexed as

COVID-19Post-Acute COVID-19 SyndromeDisease ProgressionHumansPandemicsSARS-CoV-2gene expressionimmunityinflammationSARS-CoV-2sequencing

Identifiers

PMID38203577
PMCPMC10778767
OpenAlexW4390311697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.