Evidence map›Paper›PMID 38203549›Full record

ArticleInternational journal of molecular sciences2023

Synthesis and Antibacterial Activity of Mono- and Bi-Cationic Pyridinium 1,2,4-Oxadiazoles and Triazoles.

Sara Amata, Cinzia Calà, Carla Rizzo, Ivana Pibiri, Mariangela Pizzo, Silvestre Buscemi, Antonio Palumbo Piccionello

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Recent Advances: Heterocycles in Drugs and Drug Discovery.International journal of molecular sciences · 2024
    Article
  5. Bioactive Oxadiazoles 3.0.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sara AmataDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0009-0005-8263-4633
Cinzia CalàDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro", University of Palermo, Via Del Vespro 133, 90127 Palermo, Italy.
Carla RizzoDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0002-5157-1773
Ivana PibiriDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0001-5885-164X
Mariangela PizzoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro", University of Palermo, Via Del Vespro 133, 90127 Palermo, Italy.ORCID 0000-0001-7790-2828
Silvestre BuscemiDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.
Antonio Palumbo PiccionelloDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0003-4402-5798
University of Palermo · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · IT

Funding

PNR: Next-Generation EU, DM737/2021 CUP B79J21038330001
6 · The paper itself

Abstract

One of the main causes of mortality in humans continues to be infectious diseases. Scientists are searching for new alternatives due to the fast increase in resistance of some harmful bacteria to the frontline antibiotics. To effectively treat pathogenic infections, it is crucial to design antibiotics that can prevent the development of pathogenic resistance. For this purpose, a set of 39 quaternary pyridinium and bis-pyridinium salts with different lengths of side alkyl or fluorinated chains, heterocyclic spacers, and counter ions were tested on diverse reference bacterial ATCC (American Type Culture Collection) strains, such as

Indexed as

Escherichia coliTriazolesAnti-Bacterial AgentsCationsHumansKlebsiella pneumoniaeOxadiazolesPseudomonas aeruginosaSaltsStaphylococcus aureusAnti-Bacterial AgentsCationsOxadiazolesSaltsTriazolesantibiotics resistanceoxadiazolepyridinium salts

Identifiers

PMID38203549
PMCPMC10778652
OpenAlexW4390267451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.