ReviewInternational journal of molecular sciences2023
Correlations between Dementia and Loneliness.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- How loneliness and social isolation are linked to cognitive decline among older adults? A systematic review of underlying physiological and psychobehavioral mechanisms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Risk of Psychosis among Patients with Dementia: the Roles of Loneliness, Life Satisfaction, Autonomy, Physical Health and Eyesight Loss.The Psychiatric quarterly · 2026Article
- Loneliness Subtypes and Their Association With Prevalent and Incident Dementia.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Clinical relevance of loneliness in the treatment of depression: study protocol for a naturalistic prospective longitudinal study.Frontiers in psychiatry · 2026Article
- Loneliness Prevalence and Correlates Among Community-Dwelling Older Adults in Taiwan: Clinical Utility of Brief Screening Measures.Clinical interventions in aging · 2026Article
- The Association of Hearing Impairment and Behavioral and Psychological Symptoms in Community-Dwelling Patients with Alzheimer's Disease.Psychology research and behavior management · 2026Article
- The interrelationship among physical activity, smartphone addiction, loneliness, and sport motivation in Chinese college students: a cross-sectional network analysis.Frontiers in psychology · 2026Article
- Loneliness and cognitive aging: a brain-heart axis perspective on a modifiable risk.Frontiers in aging · 2026Review
- The Role of Functional Deficits, Depression, and Cognitive Symptoms in the Perceived Loneliness of Older Adults in Mexico City.International journal of environmental research and public health · 2024Article
- Loneliness, epigenetic age acceleration, and chronic health conditions.Psychology and aging · 2024Article
- The Association Between Social Isolation and Incident Dementia Among Older Adults: Evidence From National Health and Aging Trend Study.Innovation in aging · 2024Article
- Fear of Dementia among Middle-Aged and Older Adults in Germany.Dementia and geriatric cognitive disorders extraArticle
- Brief Report: A Qualitative Analysis on the Earlier Impacts of COVID-19 on Caregivers of People With Lewy Body Dementia.Sage open agingArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes associations between dementia and loneliness on the neurobiological and epidemiological levels according to the recent body of literature. The aim of this study was to highlight major lines of research in this field. Sociocognitive skills and social interactions present complex interdependencies with dementia which may be explained by two theories. According to the first one, not sufficiently engaging in social or cognitive activities results in brain atrophy. The second one claims that brain neurogenesis and synaptic density are being increased by social connections. The relationship between loneliness and dementia could be mediated by sensory loss, including hearing and visual impairment, as well as depression and psychotic symptoms. Loneliness itself might cause a depletion in sensory and cognitive stimulation which results in a decrease in neural reserve. Certain changes in the structures of the brain caused by loneliness were found in imaging examination. Loneliness appears to be a crucial risk factor for dementia in recent times due to the modern lifestyle and consequences of the outbreak of COVID-19. Additional studies are required to understand more completely the key tenets of this topic and therefore to improve the prevention and treatment of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.