ReviewInternational journal of molecular sciences2023
How Do Classical Subtypes Correspond to Endotypes in Atopic Dermatitis?
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Peripheral Blood Skin-Homing T Cells Define Immunological Endotypes in Atopic Dermatitis: A Case-Control Study in a Mexican Population.Health science reports · 2026Article
- Membrane stability under heat stress: molecular signaling, lipid remodeling, and defense mechanisms in plants.Plant cell reports · 2026Review
- Associations of Total IgE, Eosinophils, and IL-5 with SCORAD-Defined Severity in High-IgE Atopic Dermatitis: A Retrospective Exploratory Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Identification of DNA methylation based prognostic subtype and signature in epithelial ovarian cancer.Human genetics · 2025Article
- Morpholino Knockdown in Zebrafish: A Tool to Investigate the Functional Impact of Variants of Unknown Significance in Mitochondrial Diseases.Neuromolecular medicine · 2025Review
- Updated insights into the molecular pathogenesis of canine atopic dermatitis.Veterinary dermatology · 2025Review
- Anti-Inflammatory Therapies for Atopic Dermatitis: A New Era in Targeted Treatment.Journal of clinical medicine · 2025Review
- Advancing Therapeutic Strategies in Atopic Dermatitis: Emerging Targets and Personalized Approaches.Biomolecules · 2025Review
- What is "eczema"?The Journal of dermatology · 2025Review
- Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?Frontiers in immunology · 2024Review
- Insights into Intrinsic Atopic Dermatitis: immunogenicity, Dysbiosis, and Imaging (Reflectance Confocal Microscopy, Optical Coherence Tomography).Clinical, cosmetic and investigational dermatology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since atopic dermatitis (AD) is a heterogeneous condition, the subtyping of AD is a crucial issue. The classical subtypes of AD are represented by extrinsic and intrinsic subtypes, European-American and Asian subtypes, and adult and pediatric subtypes. While the subtyping of AD was historically conducted based on the phenotype, recent findings on the mechanisms of AD have revealed the importance of the endotype, which can characterize individual patients more accurately. Considering the current development of AD therapies, AD endotyping is a prerequisite for a personalized therapeutic choice. Endotypes of AD can be stratified from different viewpoints, including cytokine expression patterns, allergen properties, epidermal barrier conditions, ceramide variation, the involvement of innate immunity, and serum biomarkers. Among them, the cytokine-based endotype seems to be the most useful one and is categorized into type 2 cytokine (IL-4, IL-13 and IL-31)-high, type 1 cytokine (IFN-
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