Evidence map›Paper›PMID 38203366›Full record

ArticleInternational journal of molecular sciences2023

Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia.

Mia Langbøl, Jens Rovelt, Arevak Saruhanian, Sarkis Saruhanian, Daniel Tiedemann, Thisayini Baskaran, Cinzia Bocca, Rupali Vohra, Barbara Cvenkel, Guy Lenaers and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Mia LangbølDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0003-4107-8990
Jens RoveltDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-4114-0267
Arevak SaruhanianDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Sarkis SaruhanianDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0001-7143-7654
Daniel TiedemannDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Thisayini BaskaranDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Cinzia BoccaFaculté de Santé, Institut MITOVASC, UMR CNRS 6015, INSERM U1083, Université d'Angers, 49933 Angers, France.ORCID 0000-0002-8822-9832
Rupali VohraDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Barbara CvenkelDepartment of Ophthalmology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-7402-1854
Guy LenaersFaculté de Santé, Institut MITOVASC, UMR CNRS 6015, INSERM U1083, Université d'Angers, 49933 Angers, France.ORCID 0000-0003-2736-3349
Miriam KolkoDepartment of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0001-8697-0734
University of Copenhagen · DKCentre National de la Recherche Scientifique · FRUniversity of Ljubljana · SI

Funding

Jørgen Bagenkop Nielsens Eye-Foundation 117138, 117139, and 119012Øjenforeningen 115774, 113846, and 114065Synoptikfonden 117140 and 118012
6 · The paper itself

Abstract

Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role. The aim of the current study was to determine and compare the effect of universal hypoxia on the metabolomic signature in plasma samples from healthy controls (

Indexed as

GlaucomaNeurodegenerative DiseasesEyeHumansHypoxiaMetabolomeenergy metabolismglaucomahypoxiametabolomicsnormal-tension glaucomaocular hypertensionoxygen stress

Identifiers

PMID38203366
PMCPMC10779258
OpenAlexW4390104146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.