SynthesisInternational journal of molecular sciences2023
Considerations about Cytotoxicity of Resin-Based Composite Dental Materials: A Systematic Review.
Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Cytotoxic Effects of Flowable Composite Resins with Different Resin Matrix Compositions on L929 Fibroblasts.Oral health & preventive dentistry · 2026Article
- Proximal Post-Curing Improves Microhardness of Class-II Resin Composite Restorations.Journal of functional biomaterials · 2026Article
- In vitro evaluation of gingiva-colored composite resins: cytotoxicity, apoptosis, and p53/NF-κB expression.Odontology · 2026Article
- Effect of glycerol-assisted ultraviolet postcuring duration on residual monomer release from 3D-printed denture base resins.Journal of Indian Prosthodontic Society · 2026Article
- Epitope-Imprinted Polymers for Selective Recognition of Bacterial Proteins: From Design to Analytical Applications.ACS measurement science au · 2026Review
- Biocompatibility and Cell Death Mechanisms Induced by PMMA-Based Dental Materials in Gingival Fibroblasts and OECM-1 Tumor Cells.Dentistry journal · 2026Article
- Cytotoxicity of Self-Etch Versus Etch-and-Rinse Dentin Adhesives After 48 h: An In Vitro Study.Dentistry journal · 2026Article
- Performance Evaluation of a Microhybrid Dental Restorative Composite Reinforced with Organoclay Nanoparticles.Polymers · 2026Article
- Evaluation of Post-Processing Time's Influence on Biocompatibility of 3D-Printed Denture Base Resins.Journal of functional biomaterials · 2026Article
- Allergenic and cytotoxic potential of (meth)acrylate monomers in dental materials: a narrative review.Frontiers in dental medicine · 2026Review
- The Effect of Shavings from 3D-Printed Patient-Specific Cutting Guide Materials During Jaw Resection on Bone Healing.Materials (Basel, Switzerland) · 2025Article
- Evaluation of the total antioxidant capacity and cytotoxicity of single shade universal resin composites.BMC oral health · 2025Article
- In Vitro Study Regarding Cytotoxic and Inflammatory Response of Gingival Fibroblasts to a 3D-Printed Resin for Denture Bases.Journal of functional biomaterials · 2025Article
- Exploring the Biological and Chemical Properties of Emerging 3D-Printed Dental Resin Composites Compared to Conventional Light-Cured Materials.Materials (Basel, Switzerland) · 2025Article
- A combined in-silico and in-vitro evaluation of cyanoacrylate-based dental materials as an adhesive for applications in prosthodontics: molecular docking and cytocompatibility analysis.The Saudi dental journal · 2025Article
- Physical-Chemical Assessment and Antimicrobial Activity of Chlortetracycline-Loaded Collagen Sponges.Materials (Basel, Switzerland) · 2025Article
- Cytotoxicity of Bulk-Fill Composites on Stem Cells from Human Exfoliated Deciduous Teeth-An In Vitro Study.Materials (Basel, Switzerland) · 2025Article
- Influence of Post-Printing Polymerization Time on the Elution of Residual Monomers and Water Sorption of 3D-Printed Resin Composite.Materials (Basel, Switzerland) · 2025Article
- Clinical Difficulties Related to Direct Composite Restorations: A Multinational Survey.International dental journal · 2025Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The dental material industry is rapidly developing resin-based composites (RBCs), which find widespread use in a variety of clinical settings. As such, their biocompatibility has gained increasing interest. This literature review presents a summary of research into the cytotoxicity of methacrylate-based composites published from 2017 to 2023. Subject to analysis were 14 in vitro studies on human and murine cell lines. Cytotoxicity in the included studies was measured via MTT assay, LDH assay, and WST-1 assay. The QUIN Risk of Bias Tool was performed to validate the included studies. Included studies (based entirely on the results of in vitro studies) provide evidence of dose- and time-dependent cytotoxicity of dental resin-based composites. Oxidative stress and the depletion of cellular glutathione (GSH) were suggested as reasons for cytotoxicity. Induction of apoptosis by RBCs was indicated. While composites remain the golden standard of dental restorative materials, their potential cytotoxicity cannot be ignored due to direct long-term exposure. Further in vitro investigations and clinical trials are required to understand the molecular mechanism of cytotoxicity and produce novel materials with improved safety profiles.
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Registered trials
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