Evidence map›Paper›PMID 38203276›Full record

ArticleInternational journal of molecular sciences2023

Role of Single-Nucleotide Polymorphisms in Genes Implicated in Capecitabine Pharmacodynamics on the Effectiveness of Adjuvant Therapy in Colorectal Cancer.

Yasmin Cura, Almudena Sánchez-Martín, Noelia Márquez-Pete, Encarnación González-Flores, Fernando Martínez-Martínez, Cristina Pérez-Ramírez, Alberto Jiménez-Morales

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yasmin CuraPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, Spain.ORCID 0000-0001-5038-0708
Almudena Sánchez-MartínPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, Spain.
Noelia Márquez-PetePharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, Spain.
Encarnación González-FloresMedical Oncology, University Hospital Virgen de las Nieves, 18014 Granada, Spain.
Fernando Martínez-MartínezPharmaceutical Care Research Group, Pharmacy Faculty, University of Granada, 18016 Granada, Spain.ORCID 0000-0002-2747-6960
Cristina Pérez-RamírezDepartment of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, 18016 Granada, Spain.
Alberto Jiménez-MoralesPharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, Spain.
Hospital Universitario Virgen de las Nieves · ESUniversidad de Granada · ES

Funding

Instituto de Salud Carlos III PT13/0010/0039
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a highly prevalent form of neoplasm worldwide. Capecitabine, an oral antimetabolite, is widely used for CRC treatment; however, there exists substantial variation in individual therapy response. This may be due to genetic variations in genes involved in capecitabine pharmacodynamics (PD). In this study, we investigated the role of single-nucleotide polymorphisms (SNPs) related to capecitabine's PD on disease-free survival (DFS) in CRC patients under adjuvant treatment. Thirteen SNPs in the

Indexed as

Colorectal NeoplasmsPolymorphism, Single NucleotideAdjuvants, ImmunologicAdjuvants, PharmaceuticAllelesCapecitabineCombined Modality TherapyHumansX-ray Repair Cross Complementing Protein 1Adjuvants, ImmunologicAdjuvants, PharmaceuticCapecitabineX-ray Repair Cross Complementing Protein 1XRCC1 protein, humancapecitabinecolorectal cancerpharmacodynamicssingle nucleotide polymorphismssurvival

Identifiers

PMID38203276
PMCPMC10778960
OpenAlexW4390014159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.