ReviewInternational journal of molecular sciences2023
Targeting Signalling Pathways in Chronic Wound Healing.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Wound Healing Potential of Multifunctional Nanomaterials: Mechanism, Future Prospects, and Challenges.Pharmaceutics · 2026Review
- Review
- Structure-Activity Relationship Evaluation of Melatonin and Its Derivatives for Wound-Healing Applications: A Combined Network Pharmacology, Molecular Docking, and Biological Validation Approach.International journal of molecular sciences · 2026Article
- Marine-Derived Polyketides fromACS pharmacology & translational science · 2026Article
- Fibrin-Based Biomaterials in Wound Healing and Soft Tissue Regeneration: Biological Mechanisms and Clinical Applications.Gels (Basel, Switzerland) · 2026Review
- Hematopoietic stem and progenitor cells derived platelet lysate promotes diabetic wound healing.Molecular medicine (Cambridge, Mass.) · 2026Article
- Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail-Implications for Disease and Regeneration.International journal of molecular sciences · 2026Review
- Honey as a Natural Flavorful Product: A Comprehensive Review of Its Potential Biological Activities and Recent Studies.Food science & nutrition · 2026Review
- Engineering synthetic agonists for targeted activation of Notch signaling.Nature chemical biology · 2026Article
- Cell-free therapeutics for non-healing wounds: role of MSC-derived exosomes in macrophage polarization, angiogenesis, and fibroblast-mediated ECM remodeling-bridging preclinical insights to clinical translation.Inflammopharmacology · 2026Review
- Electronic Skins for Advanced Wound Healing: Biomimetic Thermoregulation and Bioelectrically Active Systems.Polymers · 2026Review
- Unveiling the potential of inorganic nanoparticle-based scaffolds in wound healing: advances in antimicrobial and regenerative strategies.Nanoscale advances · 2026Review
- Spatiotemporal dynamics of mammalian wound healing.Cell discovery · 2026Review
- Research progress on TWEAK/Fn14 signaling in chronic wound healing.Frontiers in surgery · 2026Review
- Bioassay-guided fractionation and identification of wound healing active compounds from Khaya senegalensis leaves.PloS one · 2026Article
- The Yin-Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2026Article
- Molecular mechanisms of therapeutic resistance in areca nut-associated oral squamous cell carcinoma: the interplay of chronic inflammation and epithelial-mesenchymal transition.Frontiers in oncology · 2026Review
- Bioadhesive hydrogels as immunomodulatory interfaces for chronic wound healing: from microenvironmental regulation mechanism to engineering strategies.Burns & trauma · 2026Review
- Applications of Nanomaterials in Chronic Wound Healing and Scar Prevention.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds fail to achieve complete closure and are an economic burden to healthcare systems due to the limited treatment options and constant medical attention. Chronic wounds are characterised by dysregulated signalling pathways. Research has focused on naturally derived compounds, stem-cell-based therapy, small molecule drugs, oligonucleotide delivery nanoparticles, exosomes and peptide-based platforms. The phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT), Wingless-related integration (Wnt)/β-catenin, transforming growth factor-β (TGF-β), nuclear factor erythroid 2-related factor 2 (Nrf2), Notch and hypoxia-inducible factor 1 (HIF-1) signalling pathways have critical roles in wound healing by modulating the inflammatory, proliferative and remodelling phases. Moreover, several regulators of the signalling pathways were demonstrated to be potential treatment targets. In this review, the current research on targeting signalling pathways under chronic wound conditions will be discussed together with implications for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.