Evidence map›Paper›PMID 38203193›Full record

ArticleInternational journal of molecular sciences2023

High-Throughput Measure of Mitochondrial Superoxide Levels as a Marker of Coronary Artery Disease to Accelerate Drug Translation in Patient-Derived Endothelial Cells Using Opera Phenix

Weiqian E Lee, Marie Besnier, Elijah Genetzakis, Owen Tang, Katharine A Kott, Stephen T Vernon, Michael P Gray, Stuart M Grieve, Michael Kassiou, Gemma A Figtree

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Weiqian E LeeKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-2232-1759
Marie BesnierKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.
Elijah GenetzakisKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.
Owen TangKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.
Katharine A KottKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-9923-2722
Stephen T VernonKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.
Michael P GrayKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-1154-3011
Stuart M GrieveKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-2712-157X
Michael KassiouKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-6655-0529
Gemma A FigtreeKolling Institute, University of Sydney, Sydney, NSW 2006, Australia.
The University of Sydney · AU

Funding

National Health and Medical Research Council GNT2005791National Health and Medical Research Council GNT2018194NSW Office of Health and Medical Research H21/174585Therapeutic Innovation Australia n/a
6 · The paper itself

Abstract

Improved human-relevant preclinical models of coronary artery disease (CAD) are needed to improve translational research and drug discovery. Mitochondrial dysfunction and associated oxidative stress contribute to endothelial dysfunction and are a significant factor in the development and progression of CAD. Endothelial colony-forming cells (ECFCs) can be derived from peripheral blood mononuclear cells (PBMCs) and offer a unique potentially personalised means for investigating new potential therapies targeting important components of vascular function. We describe the application of the high-throughput and confocal Opera Phenix

Indexed as

Coronary Artery DiseaseHumansHuman Umbilical Vein Endothelial CellsLeukocytes, MononuclearMitochondriaSuperoxidesSuperoxidesdrug screeningendothelial colony-forming cellsendothelial dysfunctionhigh-content imaginghigh-throughput screeningmitochondriamROS

Identifiers

PMID38203193
PMCPMC10779289
OpenAlexW4389937679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.