Evidence map›Paper›PMID 38202621›Full record

ReviewMolecules (Basel, Switzerland)2023

Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications.

Ruiyin Guo, Gang Guo, Aili Wang, Gaochi Xu, Ren Lai, Hui Jin

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ruiyin GuoCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
Gang GuoThe Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming 650118, China.
Aili WangCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.ORCID 0000-0002-8124-9697
Gaochi XuCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
Ren LaiCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.ORCID 0000-0002-3123-2336
Hui JinCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China.
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) · CNKunming Institute of Zoology · CNKunming Medical University · CN

Funding

2023 Special Fund for Natural Resource Affairs (Ecological Forestry Construction) SLYJ2023B4001PI Project of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) GML2021GD0807Shenzhen New Cornerstone Science Foundation New Cornerstone Investigator Program
6 · The paper itself

Abstract

Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature's skilled predators. While only a small fraction of spiders pose a threat to humans, their venoms contain complex compounds, holding promise as drug leads. Spider venoms primarily serve to immobilize prey, achieved through neurotoxins targeting ion channels. Peptides constitute a major part of these venoms, displaying diverse pharmacological activities, and making them appealing for drug development. Moreover, spider-venom peptides have emerged as valuable tools for exploring human disease mechanisms. This review focuses on the roles of spider-venom peptides in spider survival strategies and their dual significance as pharmaceutical research tools. By integrating recent discoveries, it provides a comprehensive overview of these peptides, their targets, bioactivities, and their relevance in spider survival and medical research.

Indexed as

Biomedical ResearchSpider VenomsDrug DevelopmentHumansNeurotoxinsPeptidesNeurotoxinsPeptidesSpider Venomsbioactivityspider-venom peptidesstructuresurvival strategytherapeutics

Identifiers

PMID38202621
PMCPMC10779620
OpenAlexW4390000473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.