ArticleJournal of clinical medicine2023
The Surgical Histopathology of the Filum Terminale: Findings from a Large Series of Patients with Tethered Cord Syndrome.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Surgical Treatment of Tethered Cord Syndrome by Release of Filum Terminalis: A Review.Children (Basel, Switzerland) · 2026Review
- Diagnosis, surgery, and outcome of tethered cord syndrome in 12 dogs.Journal of veterinary internal medicine · 2026Article
- Adult tethered cord syndrome associated with spina bifida occulta and a lipomatous filum terminale: case report and structured literature review.Brain & spine · 2026Article
- Tandem Detethering: A Novel One-Stage Approach Combining Cervicothoracic Cord Release Followed by Filum Terminale Sectioning.Journal of clinical medicine · 2025Article
- The expression of GSTP1 in the filum terminale of children with tethered cord syndrome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Delayed Diagnosis of Lumbosacral Lipomyelomeningocele With Tethered Cord: A Case Report.Cureus · 2025Article
- Morphological analysis of the filum terminale and detailed description of the distal filum terminale externum: a cadaveric study.Frontiers in neuroanatomy · 2025Article
- Occult tethered cord syndrome: insights into clinical and MRI features, prognostic factors, and treatment outcomes in 30 dogs with confirmed or presumptive diagnosis.Frontiers in veterinary science · 2025Article
- Anatomical and histological characterization of the filum terminale in dogs.Frontiers in veterinary science · 2025Article
- Comorbidities and neurosurgical interventions in a cohort with connective tissue disorders.Frontiers in neurology · 2024Article
- Neuraxial biomechanics, fluid dynamics, and myodural regulation: rethinking management of hypermobility and CNS disorders.Frontiers in neurology · 2024Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the prevalence of embryonic and connective tissue elements in the filum terminale (FT) of patients with tethered cord syndrome (TCS), examining both typical and pathological histology. The FT specimens from 288 patients who underwent spinal cord detethering from 2013 to 2021 were analyzed. The histopathological examination involved routine hematoxylin and eosin staining and specific immunohistochemistry when needed. The patient details were extracted from electronic medical records. The study found that 97.6% of the FT specimens had peripheral nerves, and 70.8% had regular ependymal cell linings. Other findings included ependymal cysts and canals, ganglion cells, neuropil, and prominent vascular features. Notably, 41% showed fatty infiltration, and 7.6% had dystrophic calcification. Inflammatory infiltrates, an underreported finding, were observed in 3.8% of the specimens. The research highlights peripheral nerves and ganglion cells as natural components of the FT, with ependymal cell overgrowth and other tissues potentially linked to TCS. Enlarged vessels may suggest venous congestion due to altered FT mechanics. The presence of lymphocytic infiltrations and calcifications provides new insights into structural changes and mechanical stress in the FT, contributing to our understanding of TCS pathology.
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Registered trials
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