Evidence map›Paper›PMID 38201882›Full record

ArticleNutrients2023

In Vitro Circadian Clock Gene Expression Assessments in Mesenchymal Stem Cells from Human Infants: A Pilot Study.

Melissa L Erickson, Devin Dobias, Madeline Rose Keleher, Dana Dabelea, Bryan C Bergman, Josiane L Broussard, Kristen E Boyle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Stem Cells Run Like Clockwork for Stroke Therapeutics.Stem cell reviews and reports · 2025
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melissa L EricksonTranslational Research Institute, AdventHealth, Orlando, FL 32804, USA.
Devin DobiasDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Madeline Rose KeleherDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-9735-6155
Dana DabeleaThe Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Aurora, CO 80045, USA.
Bryan C BergmanDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Josiane L BroussardDivision of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kristen E BoyleDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-9689-3322
University of Colorado Anschutz Medical Campus · USAdventHealth Orlando · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUH3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI Traci Allison Bekelman, Dana Dabelea · 2018 to 2026
$14.8M
Exploring the Fuel-Mediated Programming of Neonatal GrowthR01DK076648 · NIDDK · UNIVERSITY OF COLORADO DENVER/HSC DENVER · PI DABELEA, DANA · 2009 to 2018
$7.0M
Time-restricted feeding to mitigate metabolic impairments during circadian misalignmentR01DK125653 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2020 to 2024
$3.3M
Epigenetic programming of infant mesenchymal stem cells: mechanisms for obesity and diabetes risk in humansR01DK117168 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BOYLE, KRISTEN ELIZABETH · 2018 to 2022
$1.7M
Impact of Shiftwork on Metabolic Flexibility and Skeletal Muscle ClocksK01DK134838 · NIDDK · ADVENTHEALTH ORLANDO · PI Melissa Erickson · 2023 to 2026
$631k
NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NIDDK NIH HHS K01 DK134838NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK076648NIDDK NIH HHS R01 DK117168NIDDK NIH HHS R01 DK125653NIH HHS K01DK134838NIH HHS P30DK048520NIH HHS R01DK076648NIH HHS R01DK117168NIH HHS R01DK125653NIH HHS UH3 OD023248NIH HHS UH3OD023248NIH HHS UL1TR001082NIH HHS UL1 TR002535
6 · The paper itself

Abstract

backgroundExposure to intrauterine obesity can disrupt clock gene rhythmicity in animal models. The aim of this pilot study was to determine if maternal obesity alters rhythmic expression of core clock in mesenchymal stem cells (MSCs) from umbilical cords of human infants born to mothers with obesity (Ob-MSC) vs. normal weight (NW-MSC).

methodsWe compared in vitro rhythmic expression patterns of core clock (

resultsWe detected significant rhythmicity in expression patterns of

conclusionRhythmic expressions of

Indexed as

Circadian ClocksMesenchymal Stem CellsAnimalsARNTL Transcription FactorsFemaleGene ExpressionHumansInfantObesityPilot ProjectsPregnancyARNTL Transcription Factorscircadianmaternalmesenchymal stem cellsobesity

Identifiers

PMID38201882
PMCPMC10780581
OpenAlexW4390176421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.