Evidence map›Paper›PMID 38201850›Full record

ArticleNutrients2023

Ketogenic Diet High in Saturated Fat Promotes Colonic Claudin Expression without Changes in Intestinal Permeability to Iohexol in Healthy Mice.

Lotta Toivio, Hanna Launonen, Jere Lindén, Markku Lehto, Heikki Vapaatalo, Hanne Salmenkari, Riitta Korpela

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lotta ToivioDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-1297-3689
Hanna LaunonenDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Jere LindénDepartment of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0001-9872-3626
Markku LehtoFolkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki, Finland.
Heikki VapaataloDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
Hanne SalmenkariFolkhälsan Institute of Genetics, Folkhälsan Research Center, 00290 Helsinki, Finland.ORCID 0000-0002-3418-152X
Riitta KorpelaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.
University of Helsinki · FI

Funding

Finnish Concordia Fund N/AFinnish Cultural Foundation N/AFinska Läkaresällskapet N/AMary and Georg C. Ehrnrooth's Foundation N/AMaud Kuistila Memorial Foundation N/ANovo Nordisk (Finland) #NNFOC0013659Paulo Foundation N/AWilhelm and Else Stockmann Foundation N/A
6 · The paper itself

Abstract

Ketogenic diets (KDs) have been studied in preclinical models of intestinal diseases. However, little is known of how the fat source of these diets influences the intestinal barrier. Herein, we studied the impact of four-week feeding with KD high either in saturated fatty acids (SFA-KD) or polyunsaturated linoleic acid (LA-KD) on paracellular permeability of the intestine to iohexol in healthy male C57BL/6J mice. We investigated jejunal and colonic tight junction protein expression, histological changes, and inflammatory markers (

Indexed as

Diet, KetogenicAlkaline PhosphataseAnimalsClaudinsInterleukin-6Intestinal Barrier FunctionIohexolLinoleic AcidMaleMiceMice, Inbred C57BLTight Junction ProteinsAlkaline PhosphataseClaudinsInterleukin-6IohexolLinoleic AcidTight Junction Proteinsdietary fatintestinal permeabilityketogenic diettight junction proteins

Identifiers

PMID38201850
PMCPMC10780785
OpenAlexW4389995518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.